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Roger Brent Phones & Addresses

  • Seattle, WA
  • 1106 Miller Ave, Berkeley, CA 94708 (510) 204-9392
  • 752 Contra Costa Ave, Berkeley, CA 94707 (510) 528-8221
  • Oakland, CA
  • Cambridge, MA
  • Boston, MA
  • Alameda, CA

Work

Position: Professional/Technical

Education

Degree: Graduate or professional degree

Resumes

Resumes

Roger Brent Photo 1

Affiliate Professor, Department Of Genome Sciences

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Location:
Seattle, WA
Industry:
Higher Education
Work:
Ucsf 2000 - 2015
Adjunct Professor of Bioengineering and Therapeutic Sciences

University of Washington 2000 - 2015
Affiliate Professor, Department of Genome Sciences

Fred Hutch 2000 - 2015
Adjunct Member, Division of Public Health Sciences

Molecular Sciences Institute Jul 2001 - Jun 2009
Research Director and President

Division of Basic Sciences Fhcrc Jul 2001 - Jun 2009
Member
Education:
Harvard University 1973 - 1982
Doctorates, Doctor of Philosophy, Molecular Biology, Biochemistry
The University of Southern Mississippi 1970 - 1973
Bachelors, Bachelor of Arts, Computer Science, Statistics
Hattiesburg High School 1970 - 1972
Skills:
Biotechnology
Molecular Biology
Science
Genomics
Biochemistry
Protein Chemistry
Microbiology
Life Sciences
Biology
Genetics
Cell Biology
R&D
Research
Laboratory
Cell
Experimentation
Bioinformatics
Purification
Lifesciences
Protein Expression
Physiology
Languages:
German
Roger Brent Photo 2

Roger Brent

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Business Records

Name / Title
Company / Classification
Phones & Addresses
Roger Brent
President, CTO
The Molecular Sciences Institute Inc
Research and Development in the Physical, Engineering, and L · Research & Development in Biotechnology · Other Professional Equipment and Supplies Merchant Wholesale
2168 Shattuck Ave FL 2, Berkeley, CA 94704
(510) 647-0690
Roger Brent
Chief Executive Officer
University of California, San Francisco
College/University Administrative Educational Programs · University Medical Center · University · College/University
(415) 502-5200, (415) 885-7257, (415) 476-2977, (415) 476-2557

Publications

Isbn (Books And Publications)

Short Protocols in Molecular Biology

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Author

Roger Brent

ISBN #

0471137812

Short Protocols in Molecular Biology: A Compendium of Methods from Current Protocols in Molecular Biology

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Author

Roger Brent

ISBN #

0471250929

Current Protocols on Cd-Rom: User's Guide

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Author

Roger Brent

ISBN #

0471306614

Short Protocols in Molecular Biology: A Compendium of Methods from Current Protocols in Molecular Biology

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Author

Roger Brent

ISBN #

0471577359

Us Patents

Interaction Trap Systems For Detecting Protein Interactions

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US Patent:
6399296, Jun 4, 2002
Filed:
Apr 9, 1996
Appl. No.:
08/630052
Inventors:
Roger Brent - Cambridge MA
John M. McCoy - Reading MA
Timm H. Jessen - Bad Soden, DE
Chanxing Wilson Xu - Boston MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12Q 168
US Classification:
435 6, 435 4, 435 78, 435 71, 436501
Abstract:
Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions.

Protein Fingerprint System And Related Methods

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US Patent:
6569685, May 27, 2003
Filed:
Oct 5, 1999
Appl. No.:
09/412732
Inventors:
Robert H. Carlson - Union City CA
Ian E. Burbulis - Kensington CA
Roger Brent - Berkeley CA
Assignee:
The Molecular Sciences Institute, Inc. - Berkeley CA
International Classification:
G01N 2162
US Classification:
436 86, 436166, 436171, 436172
Abstract:
A system and method for characterizing protein molecules. A protein molecule of interest is isolated from other types of protein molecules. The protein molecule of interest is modified to a one-dimensional structure from the natural three-dimensional structure of the protein molecule. Each of a first type of amino acid residue of the protein molecule is labeled with a first tag. Each of a second type of amino acid residue of the protein molecule is labeled with a second tag. The first and second tags impart to the protein molecule a detectable set of characteristic ancillary properties that facilitates distinction of the protein molecule of interest from other types of protein molecules. When these ancillary properties are detected, a fingerprint of the protein molecule is revealed. A listing of known protein molecules and of the fingerprints corresponding to each of the known protein molecules serves as a library to facilitate identification of unknown proteins. A fingerprint of a protein molecule of interest determined in the same manner as the fingerprints of known proteins listed in the library is compared with fingerprints of the known protein molecules to identify the protein molecule of interest.

Detection Systems For Registering Protein Interactions And Functional Relationships

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US Patent:
6858382, Feb 22, 2005
Filed:
Jan 9, 2001
Appl. No.:
09/757309
Inventors:
Roger Brent - Berkeley CA, US
C. Wilson Xu - New York NY, US
Andrew R. Mendelsohn - Sausalito CA, US
Walter L. Lok - San Francisco CA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12Q001/00
C12Q001/68
C12P021/06
G01N033/566
US Classification:
435 4, 435 6, 435 681, 435 691, 436501
Abstract:
Disclosed herein are methods for detecting complex protein interactions and protein functional relationships, and reagents for carrying out those methods.

Interaction Trap Systems For Detecting Protein Interactions

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US Patent:
20030113749, Jun 19, 2003
Filed:
Jun 4, 2002
Appl. No.:
10/162538
Inventors:
Roger Brent - Cambridge MA, US
John McCoy - Reading MA, US
Timm Jessen - Bad Soden, DE
Chanxing Xu - Boston MA, US
International Classification:
C12Q001/68
G01N033/53
G01N033/567
US Classification:
435/006000, 435/007100, 435/007210
Abstract:
Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions. Proteins isolated by these methods are also discussed. Finally, populations of eukaryotic cells are disclosed, each cell having a recombinant DNA molecule encoding a conformationally-constrained intracellular peptide.

Targeted Modification Of Intracellular Compounds

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US Patent:
20030143626, Jul 31, 2003
Filed:
Nov 13, 2001
Appl. No.:
10/066965
Inventors:
Pierre Colas - Saint Didier Mont D'Or, FR
Roger Brent - Berkeley CA, US
Barak Cohen - Cambridge MA, US
International Classification:
A61K048/00
A61K038/17
A61K038/08
G01N033/53
C07H021/04
C12P021/02
C12N005/06
C07K014/47
C07K007/08
US Classification:
435/007100, 435/069100, 435/320100, 435/325000, 514/012000, 514/013000, 514/014000, 514/044000, 536/023500, 530/324000, 530/325000, 530/326000, 530/327000
Abstract:
Disclosed are processes for specifically modulating the properties of a target molecule T, and/or of a component C, which interacts directly or indirectly with T. Also disclosed are processes for the production of a targeted effector having the capacity to specifically modulate the properties of an intracellular target molecule and/or a cellular component C which interacts directly or indirectly in the cell with the molecule. Also disclosed are effector molecules, nucleic acids encoding same and constructs e.g., vectors and host cells, containing the nucleic acids, as well as pharmaceutical compositions, and uses of the effector molecules. Further disclosed are intracellular recognition molecules containing proteinaceous recognition domains, as well as processes for identifying dimeric recognition moieties having the capacity to force an interaction between two target molecules T1 and T2, and/or a cellular component C which interacts directly or indirectly in a cell with T1 and T2.

Protein Characterization System

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US Patent:
20030198940, Oct 23, 2003
Filed:
May 23, 2003
Appl. No.:
10/444422
Inventors:
Robert Carlson - Union City CA, US
Ian Burbulis - Kensington CA, US
Roger Brent - Berkeley CA, US
Assignee:
THE MOLECULAR SCIENCES INSTITUTE, INC.
International Classification:
C12Q001/00
US Classification:
435/004000
Abstract:
A system and method for characterizing protein molecules. A protein molecule of interest is isolated from other types of protein molecules and modified into a one-dimensional structure. Each of a first type of amino acid residue of the protein molecule of interest is labeled with a first tag. Each of a second type of amino acid residue of the protein molecule is labeled with a second tag. The first and second tags impart to the protein molecule of interest a detectable set of characteristic ancillary properties that function as a fingerprint or characterization of the protein molecule of interest reflective of the physical structure of the protein molecule of interest as defined by the amino acid sequence of the protein molecule of interest. A library listing of the characterizations corresponding to protein molecules facilitates identification of protein molecules of interest.

Interaction Trap Systems For Detecting Protein Interactions

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US Patent:
20090130676, May 21, 2009
Filed:
Mar 26, 2008
Appl. No.:
12/079358
Inventors:
Roger Brent - Cambridge MA, US
John M. McCoy - Reading MA, US
Timm H. Jessen - Bad Soden, DE
Chanxing Wilson Xu - Boston MA, US
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a gene activating moiety and being conformationally-constrained; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Also disclosed are methods for assaying protein interactions, and identifying antagonists and agonists of protein interactions. Proteins isolated by these methods are also discussed. Finally, populations of eukaryotic cells are disclosed, each cell having a recombinant DNA molecule encoding a conformationally-constrained intracellular peptide.

Cdi1 Polypeptides

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US Patent:
57861692, Jul 28, 1998
Filed:
Jun 5, 1995
Appl. No.:
8/461859
Inventors:
Roger Brent - Cambridge MA
Jeno Gyuris - Arlington MA
Erica Golemis - Somerville MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12P 2106
C12N 1500
A61K 3800
US Classification:
435 691
Abstract:
Disclosed is a method for determining whether a first protein is capable of physically interacting with a second protein. The method involves: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein, the first fusion protein including the first protein covalently bonded to a binding moiety which is capable of specifically binding to the protein binding site; and (iii) a second fusion gene which expresses a second fusion protein, the second fusion protein including the second protein covalently bonded to a weak gene activating moiety; and (b) measuring expression of the reporter gene as a measure of an interaction between the first and the second proteins. Such a determination facilitates the isolation of the gene encoding the interacting protein. Also disclosed herein is recombinant Cdi1 polypeptide, nucleic acid encoding the Cdi1 polypeptide, and uses thereof.

Wikipedia References

Roger Brent Photo 3

Roger Brent

Roger Brent from Seattle, WA, age ~69 Get Report