US Patent:
20150377879, Dec 31, 2015
Inventors:
- La Jolla CA, US
Bindu Raveendra - Jupiter FL, US
Hao Wu - Jupiter FL, US
Roberto Baccala - San Diego CA, US
Argyrios Theofilopoulos - San Diego CA, US
Assignee:
THE SCRIPPS RESEARCH INSTITUTE - La Jolla CA
International Classification:
G01N 33/564
C07K 7/06
Abstract:
Combinatorial libraries were generated providing a vast number of diverse peptoid ligands. From these libraries, ligands were identified which specifically bind molecules associated with autoimmune diseases, such as antibodies specific to aquaporin-4 (AQP4), binding of which to AQP4 causes the autoimmune disease, Neuoromyelitis Optica. Methods of generating peptoid libraries and for diagnosing Neuromyelitis Optica are also provided.