Inventors:
Robert A. Mastico - Braintree MA
Peter G. Stockley - Ilkley, GB2
Simon J. Talbot - Street, GB2
Assignee:
British Technology Group Limited
International Classification:
A61K 39116
A61K 3912
C07K 14195
C12N 701
Abstract:
A chimaeric protein, suitable for incorporation in a vaccine and capable of forming parts of a capsid assembly, comprises the amino acid sequence of the coat protein of phage MS-2, or a conservatively modified variant thereof, or sufficient of said sequence or variant to retain capsid-forming capability, which amino acid sequence has been modified by insertion of a foreign epitope in the region corresponding to a protuberant protein hairpin in the capsid assembly as shown in the crystal structure of the intact phage.