Inventors:
Susana Salceda - San Jose CA, US
Roberto A. Macina - San Jose CA, US
Herve E. Recipon - San Francisco CA, US
Robert Cafferkey - San Jose CA, US
Yongming Sun - San Jose CA, US
Chenghua Liu - San Jose CA, US
Assignee:
diaDexus, Inc. - South San Francisco CA
International Classification:
C12Q001/68
C07H021/04
Abstract:
The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.