Richard M Torczynski

62422049, Jun 5, 2001

Jun 1, 2000

9/585109

Richard M. Torczynski - Farmers Branch TX
Arthur P. Bollon - Dallas TX

Cytoclonal Pharmaceutics, Inc. - Dallas TX

G01N 3300
G01N 3348
G01N 3353
G01N 33574
A61K 39395

435 723

Hybridomas secreting monoclonal antibodies specific for an epitope found in the amino acids of LCGA associated with non-small cell lung carcinoma protein have been found. The monoclonal antibodies produced by these hybridomas can be used in in vivo and in vitro clinical diagnosis of non-small cell lung carcinoma and ovarian carcinoma and as target selective carriers for various anti-tumor agents and radioimaging agents.

55895794, Dec 31, 1996

Jul 19, 1994

8/276919

Richard M. Torczynski - Dallas TX
Arthur P. Bollon - Dallas TX

Cytoclonal Pharmaceutics, Inc. - Dallas TX

C12Q 168
C07H 2102

536 231

The present invention discloses an isolated and purified nucleic acid sequence and corresponding amino acid sequence to a novel protein specific for human lung cancer cells. This gene is expressed at a much higher level in these cells than in normal lung, other normal tissues and other tumor cell lines tested. Also disclosed are two additional recombinant forms of this gene and protein, in the first case a membrane spanning region is removed and in the second case an amino acid is changed by in vitro mutagenesis. Also disclosed are nucleic acid probes for the detection of lung cancer cells from tissue biopsy and body fluids such as serum, sputum and bronchial washings. A method for expressing the antigen in a host cell and its subsequent use as an immunogen in antibody production for test applications is described. An ELISA test to measure shed antigen present in patient samples as well as an enzyme test to measure activity in specimens also is described.

61179817, Sep 12, 2000

Jun 3, 1999

9/325320

Richard M. Torczynski - Farmers Branch TX
Arthur P. Bollon - Dallas TX

Cytoclonal Pharmaceutics, Inc. - Dallas TX

A61K 39395
C12N 1506
C07K 1618
C07K 1628
C07K 1630

5303877

Hybridomas secreting monoclonal antibodies specific for an epitope found in the amino acids of LCGA associated with non-small cell lung carcinoma protein have been found. The monoclonal antibodies produced by these hybridomas can be used in in vivo and in vitro clinical diagnosis of non-small cell lung carcinoma and ovarian carcinoma and as target selective carriers for various anti-tumor agents and radioimaging agents.

57735794, Jun 30, 1998

Jan 21, 1997

8/776088

Richard M. Torczynski - Farmers Branch TX
Arthur P. Bollon - Dallas TX

Cytoclonal Pharmaceutics, Inc. - Dallas TX

C07K 1400
C07H 2100

530350

The present invention discloses an isolated and purified nucleic acid sequence and corresponding amino acid sequence to a novel protein specific for human lung cancer cells. This gene is expressed at a much higher level in these cells than in normal lung cells, other normal tissues and other tumor cell lines tested. Also disclosed are three additional recombinant forms of this gene and protein, in the first two cases a membrane spanning region is removed and in the third case an amino acid is changed by in vitro mutagenesis.