Richard R Tidwell

6423737, Jul 23, 2002

Jan 12, 2001

09/759664

James E. Hall - Chapel Hill NC
Richard R. Tidwell - Pittsboro NC
David W. Boykin - Atlanta GA

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K 3115

514399, 514438, 514471, 514633

A method of treating pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is reduced in the subject to produce a benzamidine having anti- activity. The method of the present invention may alternatively comprise intravenously administering to the subject an active compound as disclosed herein. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.

6486200, Nov 26, 2002

Jul 7, 2000

09/612138

David W. Boykin - Atlanta GA
M. Syed Rahmathullah - Mississauga, CA
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K 31357

514467, 514473, 549448, 549450, 549451

A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): wherein: X may be O, S, or NRâ wherein Râ is H or loweralkyl; R and R may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl; R and R are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl; R is represented by a formula selected from the group consisting of: âwherein: X , X , and X are independently selected from O and S; and R and R are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.

6503940, Jan 7, 2003

Jul 31, 2001

09/918787

David W. Boykin - Atlanta GA
M. Syed Rahmathullah - Mississauga, CA
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K 3140

514422, 548541, 548556, 549448, 549449, 549450, 549451, 514423

A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I): wherein: X may be O, S, or NRâ wherein Râ is H or loweralkyl, R and R may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl; R and R are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl; R is represented by a formula selected from the group consisting of: wherein: X , X , and X are independently selected from O and S; and R and R are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.

6613787, Sep 2, 2003

Dec 20, 2000

09/745004

W. David Wilson - Atlanta GA
David W. Boykin - Atlanta GA
Richard R. Tidwell - Pittsboro NC

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

A61K 31415

514394, 5483047, 549472

Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.

6635668, Oct 21, 2003

Jul 22, 1998

09/120584

Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC
Dorothy H. Wood - Hillsborough NC

The University of North Carolina at Chapel Hill - Chapel Hill NC

A61K 31343

514394, 514411, 514461, 514636, 514637

Pentamidine and analogs thereof have activity as imidazoline receptor binding compounds. A method of binding the imidazoline receptor, comprises contacting a bis-benzene to said imidazoline receptor in an amount effective to bind to said receptor, wherein said bis-benzene contains at least one amidine group (e. g. , one or two). The contacting step may be carried out in vivo or in vitro. Contacting may be carried out with individual active compounds or with libraries of active compounds.

6649652, Nov 18, 2003

Jul 30, 2002

10/208947

David W. Boykin - Atlanta GA
M. Syed Rahmathullah - Mississauga, CA
Richard R. Tidwell - Pittsboro NC
James E. Hall - Chapel Hill NC

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA

C07D31704

514467, 514473, 549229, 549448, 549449, 549451

A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by the Formula (I).

6737440, May 18, 2004

Nov 6, 2001

10/008535

David W. Boykin - Atlanta GA
Richard R. Tidwell - Pittsboro NC
W. David Wilson - Atlanta GA
John R. Perfect - Durham NC
Chad F. Stephens - Villa Rica GA

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA
Duke University - Durham NC

A61K 3127

514491, 514472, 549491, 549472

The present invention relates to novel 2,5-bis {[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula in which R , R , R and R are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R is H, alkyl or aryl; R is H, alkyl, aryl, or NR R , in which R and R are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR , in which R is H or alkyl, and to the use of such compounds.

6774144, Aug 10, 2004

Nov 1, 2000

09/703804

Christine C. Dykstra - Auburn AL
James C. Hudson - Carpenteria CA
Sandra Ewald - Auburn AL
Richard R. Tidwell - Pittsboro NC
David W. Boykin - Atlanta GA

The University of North Carolina at Chapel Hill - Chapel Hill NC
Georgia State University Research Foundation, Inc. - Atlanta GA
Auburn University - Auburn AL

A61K 3134

514461, 514472, 514473

In one aspect, the invention relates to a method of treating infectious bursal disease (IBD) in an avian subject in need of such treatment. The method comprises administering to the subject a compound of the formulas (I) through (IV) or a pharmaceutically acceptable salt thereof in an amount sufficient to treat IBD. In another aspect, the invention relates to a method of producing active immunity against infectious bursal virus disease (IBD) in an avian subject. The method comprises administering to a subject an immunogenic-amount of an IBDV vaccine and a compound selected from the compounds of formulas (I) through (IV) described herein. The compound represented by formulas (I) through (IV) is administered in an amount sufficient to induce an immune response in the avian subject.