Inventors:
Herman Rutner - Hackensack NJ
Raul Rapun - Suffern NY
Nathan Lewin - New York NY
Assignee:
Becton, Dickinson & Company - Rutherford NJ
International Classification:
C07J 1900
Abstract:
Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1## Wherein R' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or fumaryl, preferably succinyl, and X is hydroxyl or alkali metal salt thereof; a protein conjugate; a peptide conjugate; or an amino acid or amnio acid ester radical. The radiolabeled compounds are used in the radioimmunological assay of digoxin. The preferred compound is radioiodinated 3-succinyl digoxigenin-L-tyrosine.