US Patent:
20070264257, Nov 15, 2007
Inventors:
Kyriaki Dunussi-Joannopoulos - Belmont MA, US
Anand Iyer - Randolph NJ, US
International Classification:
A61K 39/395
A61K 45/00
A61P 37/00
US Classification:
424132100, 424130100, 424133100, 424135100, 424142100, 424144100, 424278100, 514789000
Abstract:
Compositions and methods for treating autoimmune diseases are described. In particular, the use of B cell depleting agents and cytotoxic drug/B cell depleting agent conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) in treating autoimmune diseases is described. Combination therapies and compositions for treating autoimmune diseases, including the B cell depleting agents, conjugates and/or anti-cytokine agents, are also described.