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Ramakrishnan N Seshadri

from Alexandria, VA
Age ~85

Ramakrishnan Seshadri Phones & Addresses

  • 4908A John Ticer Dr, Alexandria, VA 22304
  • 2025 Griffith Rd, Falls Church, VA 22043
  • 8664 Sandpoint Dr, Germantown, TN 38139 (901) 754-4839
  • Fairfax, VA
  • 1212 Morningside Ln, Alexandria, VA 22308 (901) 674-0715

Work

Position: Sales Occupations

Education

Degree: Associate degree or higher

Resumes

Resumes

Ramakrishnan Seshadri Photo 1

Ramakrishnan Seshadri

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Publications

Us Patents

N-Alkyl And N-Benzyl Adriamycin Derivatives

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US Patent:
46109773, Sep 9, 1986
Filed:
Apr 8, 1985
Appl. No.:
6/720697
Inventors:
Mervyn Israel - Germantown TN
Ramakrishnan Seshadri - Germantown TN
Assignee:
The University of Tennessee Research Corporation - Knoxville TN
International Classification:
A61K 3171
C07H 1524
US Classification:
514 34
Abstract:
Compounds having the structure ##STR1## in which A is alkanoate having from 4 to 10 carbon atoms, hemiadipate, or hemiglutarate, and R. sub. 1 and R. sub. 2 are n-propyl, or n-butyl, or R. sub. 1 is hydrogen, n-propyl or n-butyl and R. sub. 2 is benzyl, and their corresponding non-toxic pharmacologically acceptable acid salts. The compounds are useful as active agents in therapeutic compositions having antitumor activity.

Hybrid Nitrosoureidoanthracyclines Having Antitumor Activity

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US Patent:
49736752, Nov 27, 1990
Filed:
Apr 13, 1989
Appl. No.:
7/338031
Inventors:
Mervyn Israel - Germantown TN
Ramakrishnan Seshadri - Germantown TN
Assignee:
University of Tennessee Research Center - Knoxville TN
International Classification:
C07H 1524
US Classification:
536 64
Abstract:
N-2-chloroalkyl nitrosouredio derivatives of anthracycline-based compounds having antitumor activity are disclosed. Relative to the clinically-used drugs adriamycin and daunorubicin, substantially enhanced antitumor activity against parent murine P388 leukemia and an adriamycin-resistant P388 leukemia subline has been found for the N-2-chloroethylnitrosoureido derivatives of adriamycin, daunorubicin and epirubicin. Chemical stability has been found to be enhanced when employing the 4'-epi stereoisomeric family of these compounds.
Ramakrishnan N Seshadri from Alexandria, VA, age ~85 Get Report