Inventors:
Travis L. BIECHELE - Seattle WA, US
Andy J. CHIEN - Kirkland WA, US
Randall T. MOON - Kenmore WA, US
Rima KULIKAUSKAS - Seattle WA, US
Rachel TORONI - Auburn WA, US
Assignee:
UNIVERSITY OF WASHINGTON - Seattle WA
International Classification:
A61K 31/506
A61K 31/4184
A61K 31/277
C12Q 1/68
A61P 35/00
G01N 33/566
C40B 30/04
A61K 31/437
A61K 31/4439
US Classification:
514272, 514300, 514394, 514523, 514341, 436501, 435 792, 435 721, 506 9, 435 612
Abstract:
The present disclosure relates to the regulation and function of the Wnt/β-catenin signaling pathway and the ERK signaling pathway. The disclosure provides methods of treatment for melanoma by administering both an inhibitor of ERK signaling and an activator of Wnt/β-catenin signaling. These methods may be used alone or in combination with other strategies targeting melanoma cell survival. The disclosure also provides diagnostic methods for predicting a patient's clinical response to inhibitors of ERK signaling.