Qinghai G Zhao

20080057004, Mar 6, 2008

Aug 7, 2007

11/835114

Adam Bell - Germantown MD, US
Craig Rosen - Laytonsville MD, US
Indrajit Sanyal - Bethesda MD, US
Qinghai Zhao - Gaithersburg MD, US

A61K 9/12
A61K 38/28
A61P 3/10
C07K 14/00
C12N 1/00
C12N 15/62
C12N 15/63
C12P 21/04

424046000, 424045000, 435243000, 435069700, 514003000, 530303000, 536023400

Disclosed are fusion proteins that include albumin fused to a polypeptide that has insulin activity. The fusion proteins may include albumin fused to insulin or an insulin analog. In particular, the fusions proteins may include albumin fused to a single chain insulin analog. The fusion proteins may exhibit extended insulin activity in vivo or in vitro relative to insulin that is not fused to albumin. The fusion proteins may be formulated as aerosol compositions.

20140199283, Jul 17, 2014

Jan 14, 2014

14/155021

Qinghai Zhao - North Potomac MD, US
Xia Luo - Rockville MD, US
Jason Bock - North Potomac MD, US

TEVA PHARMACEUTICAL INDUSTRIES, LTD. - Petach-Tikva

A61K 47/48
B65B 3/04
A61J 1/00

424 943, 206438, 53467

The present invention provides an aqueous pharmaceutical composition comprising the fusion protein whose amino acid sequence is set forth as SEQ ID No:1 and an aqueous solution comprising 40 to 60 mM sodium phosphate. The present invention further provides a lyophilized pharmaceutical composition, an reconstituted solution, a sealed package comprising the lyophilized pharmaceutical composition, and a vial comprising the lyophilized pharmaceutical or the reconstituted solution. The present invention also provides a method of producing the lyophilized pharmaceutical composition and the sealed package. The present invention also provides a method of treating a human having cocaine seeking behavior, and methods of using the aqueous pharmaceutical composition and lyophilized pharmaceutical composition.

20140199286, Jul 17, 2014

Jan 14, 2014

14/155056

Qinghai Zhao - North Potomac MD, US
Xia Luo - Rockville MD, US
Jason Bock - North Potomac MD, US

TEVA PHARMACEUTICAL INDUSTRIES, LTD. - Petach-Tikva

A61J 3/00
A61K 38/38
A61K 38/46

424 946, 435197, 53467

The present invention provides a process for producing a lyophilized pharmaceutical composition containing a protein. The present invention further provides a product produced by the process. The present invention further provides a process for producing an injectable pharmaceutical composition. The present invention further provides a method of treating a patient with a therapeutic protein composition.