US Patent:
20110064668, Mar 17, 2011
Inventors:
Julita S. Imperial - Midvale UT, US
Baldomero M. Olivera - Salt Lake City UT, US
Paul F. Alewood - Queensland, AU
Heinz Terlau - Eckernfoerde, DE
David J. Craik - Queensland, AU
Estuardo Lopez-Vera - Salt Lake City UT, US
Pradip K. Bandyopadhyay - Salt Lake City UT, US
Assignee:
UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT
THE UNIVERSITY OF QUEENSLAND - Brisbane, QLD
MAX-PLANCK SOCIETY - Munich
International Classification:
A61K 49/00
C07K 14/435
C07H 21/04
A61K 38/17
A61P 25/00
US Classification:
424 92, 530324, 530322, 536 235, 514 213, 514 209
Abstract:
The invention relates to relatively short peptides (termed J-Superfamily conotoxin peptides, J-conotoxins or J-conotoxin peptides herein), about 25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The J-conotoxins are useful for treating disorders involving voltage gated ion channels and/or receptors.