US Patent:
20080064764, Mar 13, 2008
Inventors:
George Ekema - Lakewood OH, US
Pieter Faber - Westlake OH, US
Benjamin Faga - University Heights OH, US
Gregory Foust - Euclid OH, US
John Harrington - Mentor OH, US
Paul Jackson - Shaker Heights OH, US
Robert Mays - Cleveland Heights OH, US
International Classification:
A61K 45/00
A61P 19/10
A61P 35/00
C07H 21/04
C07K 14/705
C07K 16/28
C12N 15/85
C12N 5/10
C12P 21/06
C12Q 1/68
G01N 33/53
US Classification:
514789000, 435320100, 435325000, 435006000, 435069100, 435007100, 530350000, 530388220, 530389100, 536023500
Abstract:
The current disclosure provide a novel human calcium sensing receptor named CaR2 and the nucleotide sequence that encodes the receptor. The disclosure further provides antibodies specific for CaR2. Also disclosed are methods of identifying modulators of the receptor and methods of using the identified modulators to treat calcium receptor mediated conditions.