Inventors:
Peter R. Oeltgen - Winchester KY
Craig J. McClain - Lexington KY
Shirish Barve - Lexington KY
Paul D. Bishop - Fall City WA
Assignee:
University of Kentucky Research Foundation - Lexington KY
ZymoGenetics - Seattle WA
International Classification:
A61K 3808
US Classification:
514 16, 514 2, 514893, 514894, 514937, 530300, 530302
Abstract:
A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0. 5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.