Patricia D Palena

20090220382, Sep 3, 2009

Jan 2, 2009

12/348128

Patricia D. Palena - Plainsboro NJ, US
Tammie L. Borders - Justin TX, US
Jeffrey A. Stuart - Columbia CT, US

LOCKHEED MARTIN CORPORATION - Bethesda MD

G01N 33/543
A61B 5/00

422 681, 436518, 600300, 977904

A nano-structured device for detecting biological analytes, chemical, analytes, cancer and other physiological conditions, includes a carrier substrate, a transducer film disposed over a surface of the carrier substrate, and a dendrimer structure tethered to the transducer film. The transducer film generates a first signal in response to a mechanical stress applied thereto. The first signal indicates the detection of the biological analyte, chemical analyte, cancer or other physiological condition. The dendrimer structure includes a plurality of receptors for binding the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological conditions to the dendrimer structure. The dendrimer structure applies the mechanical stress to the transducer film, which is proportional to the strain induced into the dendrimer by the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological condition binding to the receptors, the mechanical stress causing the transducer film to generate the first signal indicating the detection of the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological condition.

20130018243, Jan 17, 2013

Jul 13, 2012

13/549198

Patricia D. PALENA - Plainsboro NJ, US
Madiha JAFRI - Mount Laurel NJ, US
Jason POLESKI - Moorestown NJ, US
Sanipa K. ARNOLD - Huntingdon Valley PA, US

LOCKHEED MARTIN CORPORATION - Bethesda MD

A61B 5/145
G01N 27/00
B82Y 15/00

600345, 422 69, 977742

A biosensor includes a microfluidics layer, a transduction layer and a transceiver layer. The transduction layer further includes a functionalized layer that reacts with a biomarker, and a plurality of carbon nanotubes adjacent the functionalized layer. The conductivity of the carbon nanotubes changes in response to a biomarker reacting with at least a portion of the functionalized layer. The functionalized layer can include dendrimers, such as a tadpole dendrimer scaffolding that includes a plurality of sites for receiving receptors for biomarkers.

20130040405, Feb 14, 2013

Aug 13, 2012

13/584419

Laura Segatori - Houston TX, US
Sibani Lisa Biswal - Houston TX, US
Jinghui Wang - Houston TX, US
Patricia D. Palena - Plainsboro NJ, US
Michael J. DiMario - Skillman NJ, US

Lockheed Martin Corporation - Moorestown NJ
William Marsh Rice University - Houston TX

G01N 33/557
G01N 29/036
G01N 21/21
G01N 21/55

436501

In some embodiments, the present invention provides methods of detecting a molecule in a sample, such as an explosive. In some embodiments, the method comprises: associating the sample with an antigen/binding agent complex; measuring a rate of displacement of the binding agent from the antigen by the molecule in the sample; and correlating the measured rate of displacement to the presence of the molecule in the sample. In some embodiments, the measuring step comprises a determination of a change in frequency of the sample and a change in energy dissipation of the sample over a time interval. In some embodiments, the correlating step comprises a calculation of a ratio of a change in energy dissipation of the sample over a change in frequency of the sample over the time interval. In some embodiments, the method is used to determine the molecule concentration in the sample.