US Patent:
20080118530, May 22, 2008
Inventors:
Olen M. Kew - Alpharetta GA, US
Cara C. Burns - Avondale Estates GA, US
Jing Shaw - Decatur GA, US
Raymond Campagnoli - Decatur GA, US
Jacqueline Quay - Chapel Hill NC, US
International Classification:
A61K 39/00
C12N 15/00
A61K 39/12
A61K 39/02
A61P 37/00
A61K 39/002
C12N 15/74
US Classification:
4242071, 435440, 435471, 4241841, 4242041, 4242341, 4242691, 4242741, 4242211, 4242291, 4242191
Abstract:
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.