Inventors:
- South San Francisco CA, US
John R. Jacobsen - San Mateo CA, US
Anne-Marie Beausoleil - Redwood City CA, US
Gary E. Brandt - Alameda CA, US
Melissa Fleury - Brisbane CA, US
Lan Jiang - Foster City CA, US
Cameron Smith - San Bruno CA, US
Steven D.E. Sullivan - San Francisco CA, US
Lori Jean Van Orden - San Francisco CA, US
Pierre-Jean Colson - San Francisco CA, US
Gene Timothy Fass - San Francisco CA, US
Miroslav Rapta - San Carlos CA, US
Noah Benjamin - San Francisco CA, US
Marta Dabros - Foster City CA, US
Venkat R. Thalladi - Foster City CA, US
Assignee:
THERAVANCE BIOPHARMA R&D IP, LLC - South San Francisco CA
International Classification:
C07D 471/04
Abstract:
The invention provides compounds of formula (I):wherein X isand the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.
