US Patent:
20090082304, Mar 26, 2009
Inventors:
Kulsoom Ghias - Chicago IL, US
Chunguang Ma - Champaign IL, US
Varsha Gandhi - Houston TX, US
Leonidas C. Platanias - Glencoe IL, US
Nancy L. Krett - Elk Grove Village IL, US
Steven T. Rosen - Evanston IL, US
Assignee:
NORTHWESTERN UNIVERSITY - Evanston IL
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM - AUSTIN TX
International Classification:
A61K 31/7076
A61K 31/70
G01N 33/53
C12Q 1/02
C12Q 1/48
C12Q 1/42
C12Q 1/37
A61P 35/00
US Classification:
514 46, 514 43, 436 86, 435 29, 435 15, 435 21, 435 24
Abstract:
The present invention provides methods of treating hematological malignancies, including multi-drug resistant malignancies, with 8-amino-adenosine and variants thereof. Also encompassed by the present invention is a method of predicting the response of a patient diagnosed with a hematological malignancy to treatment with a nucleoside analog and a method of screening candidate drugs for efficacy in treating hematological malignancies.