Inventors:
Ziwei Huang - Philadelphia PA
Zhaowen Luo - Philadelphia PA
Naiming Zhou - Bala Cynwyd PA
Jiansong Luo - Philadelphia PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 3800
US Classification:
514 12, 424 851, 435 691, 530300, 530324, 530333, 530351
Abstract:
Synthetic peptide analogs of chemokines are designed to include the N- and C-terminal portions of the corresponding naturally occurring chemokine. In particular, synthetic peptide analogs of stromal cell-derived factor-1 (SDF-1) are effective in inhibiting HIV-1 entry and infection via the CXC chemokine receptor 4 (CXCR4). Each peptide comprises a peptide segment analog of the SDF-1 N-terminal region joined to a peptide segment analog of the SDF-1 C-terminal region. The peptides are useful for HIV treatment and prophylaxis.
