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Motoo Nagane Phones & Addresses

  • Carlsbad, CA
  • San Diego, CA

Publications

Us Patents

Methods To Modulate The Resistance Of Cells To Apoptosis Mediated By Mutant Epidermal Growth Factor Receptors

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US Patent:
20010051628, Dec 13, 2001
Filed:
May 4, 1998
Appl. No.:
09/071541
Inventors:
MOTOO NAGANE - SAN DIEGO CA, US
WEBSTER K. CAVENEE - LA JOLLA CA, US
ALEXANDER LEVITZKI - BURLA, IL
AVIV GAZIT - NOF HARIM, IL
International Classification:
A61K031/33
A61K031/505
A61K033/24
C07D239/00
C07D491/00
A61K031/44
US Classification:
514/259000, 514/183000, 514/449000, 424/649000, 423/351000, 540/478000, 544/253000
Abstract:
The present invention provides methods and compositions for enhancing the activity of various therapeutic agents that induce apoptosis by modulating the apoptosis-inhibiting effects of the expression products of mutant epidermal growth factor receptor (EGFR) genes. Methods and compositions of particular use in the treatment of cancers, such as glioma, that express such a mutant EGFR gene are provided.

Compositions Of Trail And Dna Damaging Drugs And Uses Thereof

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US Patent:
6444640, Sep 3, 2002
Filed:
Sep 30, 1999
Appl. No.:
09/409336
Inventors:
Motoo Nagane - La Jolla CA
Webster Cavenee - La Jolla CA
Su Huang - La Jolla CA
Assignee:
Ludwig Institute for Cancer Research - New York NY
International Classification:
A61K 3800
US Classification:
514 2
Abstract:
The invention relates to compositions which include both a DR5 binding ligand, such as TRAIL, and a DNA damaging agent. In combination, these two materials have unexpected efficacy in treating conditions involving rapid cellular turnover, such as cancer, where an increase in apoptosis is desired. The compositions are particularly effective in treating neoplasias and diseases involving proliferative lesions, such as glioma.
Motoo M Nagane from Carlsbad, CA, age ~66 Get Report