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Mitchel J Doktycz

from Knoxville, TN

Mitchel Doktycz Phones & Addresses

  • 1405 Rush Limbaugh Ln, Concord, TN 37922 (865) 675-3890
  • Knoxville, TN
  • 1501 Jackson Ave, River Forest, IL 60305 (708) 214-7385
  • Oak Park, IL

Publications

Us Patents

Micro-Machined Calorimetric Biosensors

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US Patent:
6436346, Aug 20, 2002
Filed:
Sep 14, 1999
Appl. No.:
09/395630
Inventors:
Mitchel J. Doktycz - Knoxville TN
Stephen F. Smith - Loudon TN
Patrick I. Oden - Plano TX
William L. Bryan - Knoxville TN
James A. Moore - Powell TN
Thomas G. Thundat - Knoxville TN
Robert J. Warmack - Knoxville TN
Assignee:
U T Battelle, LLC - Oak Ridge TN
International Classification:
G01N 2520
US Classification:
422 51, 436147, 73 2406, 73 2501, 374 45, 374 12, 438 54
Abstract:
A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.

Dual Manifold System And Method For Fluid Transfer

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US Patent:
6569687, May 27, 2003
Filed:
Dec 15, 2000
Appl. No.:
09/738821
Inventors:
Mitchel J. Doktycz - Knoxville TN
William Louis Bryan - Knoxville TN
Reid Kress - Oak Ridge TN
Assignee:
UT-Battelle, LLC - Oak Ridge TN
International Classification:
G01N 110
US Classification:
436180, 436174, 422100, 7386417, 7386332, 73864, 7386401, 7386402, 7386411
Abstract:
A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

Dual Manifold System And Method For Fluid Transfer

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US Patent:
6627157, Sep 30, 2003
Filed:
Mar 4, 1999
Appl. No.:
09/262455
Inventors:
Mitchel J. Doktycz - Knoxville TN
William Louis Bryan - Knoxville TN
Reid Kress - Oak Ridge TN
Assignee:
UT-Battelle, LLC - Oak Ridge TN
International Classification:
B01L 302
US Classification:
422100, 436180, 73864, 7386401, 7386411, 7386402, 7386332, 7386417
Abstract:
A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

Hybrid Valve Apparatus And Method For Fluid Handling

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US Patent:
6852291, Feb 8, 2005
Filed:
Oct 11, 2000
Appl. No.:
09/689548
Inventors:
James E. Johnson - Sebastopol CA, US
Neil R. Picha - Petaluma CA, US
Mitchel J. Doktycz - Knoxville TN, US
Assignee:
Innovadyne Technologies, Inc. - Rohnert Park CA
International Classification:
B01L003/02
G01N001/10
E03B011/01
E03C001/18
US Classification:
422103, 422100, 436180, 137597, 13762546
Abstract:
A hybrid valve apparatus for use with an aspiration actuator and a dispensing actuator to transfer fluid from a reservoir to a test site on a substrate surface. The hybrid valve includes a valve assembly movable between an aspiration condition and a dispensing condition, and a manifold device coupled to the valve assembly. The manifold device includes a fluid aspiration conduit having a first aspiration port in fluid communication with the aspiration actuator. On an opposite end of the aspiration conduit is a second aspiration port in selective fluid communication with the valve assembly to selectively aspirate a liquid sample slug from the reservoir into a discrete sample path when the valve assembly is in the aspiration condition. The manifold device further includes a fluid dispensing conduit having a first dispensing port in fluid communication with the dispensing actuator, and a second dispensing port in selective fluid communication with the valve assembly. When the valve assembly is in the dispensing condition, the sample path is fluidly coupled to the dispensing actuator to selectively dispense at least one droplet of the liquid sample slug therefrom, while simultaneously being out of fluid communication with the aspiration actuator.

Nanoconduits And Nanoreplicants

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US Patent:
7229692, Jun 12, 2007
Filed:
Feb 9, 2004
Appl. No.:
10/774699
Inventors:
Anatoli V. Melechko - Oak Ridge TN, US
Timothy E. McKnight - Greenback TN, US
Michael A. Guillorn - Ithaca NY, US
Bojan Ilic - Ithaca NY, US
Vladimir I. Merkulov - Knoxville TN, US
Mitchel J. Doktycz - Knoxville TN, US
Douglas H. Lowndes - Knoxville TN, US
Michael L. Simpson - Knoxville TN, US
Assignee:
UT-Battelle LLC - Oak Ridge TN
International Classification:
B32B 9/04
US Classification:
428446, 428131, 428137, 977781, 977784
Abstract:
Methods, manufactures, machines and compositions are described for nanotransfer and nanoreplication using deterministically grown sacrificial nanotemplates. An apparatus includes a substrate and a nanoconduit material coupled to a surface of the substrate, where the substrate defines an aperture and the nanoconduit material defines a nanoconduit that is i) contiguous with the aperture and ii) aligned substantially non-parallel to a plane defined by the surface of the substrate. An apparatus includes a substrate and a nanoreplicant structure coupled to a surface of the substrate.

Apparatus And Method For Testing And Continuously Reading Low-Volume Samples

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US Patent:
7232547, Jun 19, 2007
Filed:
Mar 21, 2003
Appl. No.:
10/394811
Inventors:
Terry L. Rusch - Marshfield WI, US
James L. Weber - Marshfield WI, US
Mitchel J. Doktycz - Knoxville TN, US
Kim M. Fieweger - Marshfield WI, US
Jon P. Chudyk - Marshfield WI, US
J. Steven Hicks - Knoxville TN, US
Jianhong Che - Marshfield WI, US
Assignee:
Marshfield Clinic - Marshfield WI
International Classification:
B32B 5/02
US Classification:
422 66, 422 8205, 422 99, 422100, 422101, 436 94, 436172, 436180, 4352872
Abstract:
The present invention is directed to a well sampling tape (otherwise known as “microwell tape” or simply “tape”), a dispenser for dispensing small volumes of liquid into the wells formed in the tape and a detector for high-throughput sample reading of the liquid dispensed in the individual wells. The present invention is more specifically directed to a bioassay system incorporating the materials listed above.

Hybrid Valve Apparatus And Method For Fluid Handling

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US Patent:
7497995, Mar 3, 2009
Filed:
Jan 11, 2005
Appl. No.:
11/034389
Inventors:
James E. Johnson - Sebastopol CA, US
Neil R. Picha - Petaluma CA, US
Mitchel J. Doktycz - Knoxville TN, US
Assignee:
Innovadyne Technologies, Inc. - Rohnert Park CA
International Classification:
B01L 3/02
US Classification:
422100, 422 99, 422103, 422 63, 422 64, 7386325, 73864
Abstract:
A hybrid valve apparatus for use with an aspiration actuator and a dispensing actuator to transfer fluid from a reservoir to a test site on a substrate surface. The hybrid valve includes a valve assembly movable between an aspiration condition and a dispensing condition, and a manifold device coupled to the valve assembly. The manifold device includes a fluid aspiration conduit having a first aspiration port in fluid communication with the aspiration actuator. On an opposite end of the aspiration conduit is a second aspiration port in selective fluid communication with the valve assembly to selectively aspirate a liquid sample slug from the reservoir into a discrete sample path when the valve assembly is in the aspiration condition. The manifold device further includes a fluid dispensing conduit having a first dispensing port in fluid communication with the dispensing actuator, and a second dispensing port in selective fluid communication with the valve assembly. When the valve assembly is in the dispensing condition, the sample path is fluidly coupled to the dispensing actuator to selectively dispense at least one droplet of the liquid sample slug therefrom, while simultaneously being out of fluid communication with the aspiration actuator.

Oligonucleotide Probes For Genosensor Chips

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US Patent:
7539579, May 26, 2009
Filed:
Apr 9, 2003
Appl. No.:
10/410040
Inventors:
Kenneth L. Beattie - Crossville TN, US
Mitchel J. Doktycz - Knoxville TN, US
Alfonso Mendez-Tenorio - 08720 Mexico City, MX
Rogelio Maldonado-Rodriguez - 11420, Mexico City, MX
Armando Guerra-Trejo - 02080, Mexico City, MX
International Classification:
G06F 19/00
C12Q 1/68
US Classification:
702 19, 435 6
Abstract:
Software for designing optimized sets of oligonucleotide probes for use in genosensors (oligonucleotide microarrays) is disclosed. The selection of probe sequences is based on multiple criteria including thermal stability of the probe-target pairs, similarity degree of the probes with respect to other DNA sequences, and evaluation of the secondary structure of target molecules. The programs were written in the programming language Borland Delphi by means of Object-Oriented Programming (OOP) techniques. The Genosensor Probe Design computer program disclosed herein facilitates the design of optimized arrays of probes which accurately represents the characteristics of the nucleic acid molecule under study, such as its identity or its differences in sequence or abundance with respect to other molecules.
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