Inventors:
Roland E. Dolle - King of Prussia PA, US
Bertrand Le Bourdonnec - East Fallowfield PA, US
Christopher W. Ajello - Lansdale PA, US
Minghua Gu - Collegeville PA, US
Guo-Hua Chu - Wilmington DE, US
Lara K. Leister - Shillington PA, US
Assignee:
Adolor Corporation - Exton PA
International Classification:
A61K 31/438
C07D 491/10
Abstract:
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.