Miner N Munk

49420186, Jul 17, 1990

Mar 23, 1989

7/328750

Miner N. Munk - Lake Park FL

LDC Analytical Inc. - Riviera Beach FL

G01N 3002

422 70

Solvent composition gradients in high performance liquid chromatography (HPLC) are generated with a packed bed gradient generator. Natural dispersion occurs in flow through a bed of particles due to eddy and molecular diffusion. This dispersion changes a sharply defined front between two solvents into a desirable error function type gradient profile at the interface between the solvents. The packed-bed gradient generator is a cylindrical tube filled with chemically inert glass beads. Other axial column contours such as a double taper column or bell-shaped entrance and exit regions can be used to tailor the gradient profile. The static packed-bed gradient generator can be placed either on the low pressure inlet side of the high pressure pump, or the high pressure outlet side of the pump. While low pressure operation may provide added convenience, high pressure operation provides additional pulse dampening ability. The high pressure placement of the packed-bed generator would be the only option for use with syringe pumps common in microbore HPLC.

62819755, Aug 28, 2001

Mar 7, 2000

9/521071

Miner N. Munk - Sonoma CA

Eldex Laboratories, Inc. - Napa CA

G01N 2100

356440

A bent capillary flow cell with protruding end bulbs coaxial with centerline of an elongated center cylindrical section of capillary tubing. The bulbs provide a high light throughput entrance window for the cell. Light is piped along the elongated center section by total internal reflection at the outside surface of the cell wall. An external light absorbing band is placed in optical contact with outer surface of the cell wall over a transition cone region between the bulb and center cylindrical section of the cell. Each of the external light absorbing bands extend a short prescribed distance over the cylindrical wall to absorb light rays that would otherwise be light piped within the cell wall and have little exposure to the liquid in the cell.

44578466, Jul 3, 1984

Jul 8, 1982

6/396389

Miner N. Munk - Riviera Beach FL

Milton Roy Company - St. Petersburg FL

B01D 1508

210656

In the analysis of substances by liquid chromatography, samples to be analyzed are introduced into the chromatography column by being loaded into a fluid permeable section in a cartridge, placing the sample loaded section over the inlet end of the column and flowing solvent through such section into the column. The cartridge may be a plate with an opening through it with the ends of the opening covered by permeable membranes or the opening may be packed with porous material. The cartridge may have a plurality of such openings and these may be in the form of a line on a rectangular plate or a circle on a circular plate. The new methods and devices of the invention are particularly useful in micro-scale liquid chromatographic procedures.

56085176, Mar 4, 1997

Feb 28, 1995

8/395784

Miner N. Munk - Sonoma CA

Thermo Separation Products Inc. - Fremont CA

G01N 2105

356246

A coated flow cell and a method for making the coated flow cell are provided. The flow cell comprises a flow passage internally coated with a polymer having an index of refraction lower than that of water. In this manner, light directed into the flow cell is internally reflected or "piped" down the length of the flow passage. As a result, flow cells having path lengths significantly longer and accepting incident angles of light much greater than possible with prior art flow cells. A method for internally coating the flow cell is also provided.

47476877, May 31, 1988

Aug 14, 1986

6/898730

Thomas Hoppe - Palm Beach FL
Miner Munk - Palm Beach FL

Milton Roy Company - St. Petersburg FL

G01N 2105
G01N 2185

356246

A detector cell assembly for spectrophotometry has a radiation transparent spherical ball closing the opening in a cell body through which radiation passes. The spherical ball is of fused silica or sapphire and is pressed the cell body in a direct seal. The radiation has a crossed ray pattern within the cell.

61992577, Mar 13, 2001

Jun 14, 1996

8/663993

Miner Nelson Munk - Sonoma CA
Douglas Alan Perry - Palm Beach Gardens FL
Brian Robert Said - Jupiter FL

Thermo Separation Products, Inc. - San Jose CA

B23P 2500

29423

A process for making a flow cell having an internal flow passage of a material having a refractive index less than that of water or having the internal walls of the flow passage coated or otherwise covered with such a material is provided. The flow cell so produced substantially totally internally reflects light along the cell bore.

44758138, Oct 9, 1984

Aug 30, 1982

6/413220

Miner N. Munk - Riviera Beach FL

Milton Roy Company - St. Petersburg FL

G01N 2159
G01N 2164

356 73

Improved optical systems for liquid chromatographic apparatus comprise flow cells with light transparent portions through which one or more beams of light may be passed through an effluent stream flowing in the cell, one or more light sources on one side of the flow cell to project light through the cell and its contained effluent stream, one or more light limiting apertures positioned on the opposite side of the cell in the paths of the light beams, one or more positive light focusing elements positioned in the path of the light beams from the cell to the apertures to image the center of the cell at the apertures and a light sensor positioned in the path of the light beam on the side of each aperture opposite to its respective light focusing element. Improved methods of chromatographic analysis using the new optical systems are also disclosed.