Inventors:
David J. Augeri - Princeton NJ, US
Marianne Carlsen - Yardley PA, US
Kenneth G. Carson - Princeton NJ, US
Qinghong Fu - Plainsboro NJ, US
Jason P. Healy - Flemington NJ, US
Theodore C. Jessop - Lawrenceville NJ, US
Philip E. Keyes - Flemington NJ, US
Min Shen - Pennington NJ, US
James E. Tarver - Morrisville PA, US
Jerry A. Taylor - Trenton NJ, US
Xiaolian Xu - Princeton NJ, US
Assignee:
Lexicon Pharmaceuticals, Inc. - The Woodlands TX
International Classification:
C07D 403/14
A61K 31/506
US Classification:
5142358, 514241, 51425218, 514257, 51426321, 514274, 544122, 544194, 544250, 544277, 544296, 544317
Abstract:
O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:.