Inventors:
David Scott Edwards - Burlington MA
Milind Rajopadhye - Westford MA
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
A61K 4904
US Classification:
424 94, 424 111, 424 165, 424 169, 424 91, 534 10, 534 14
Abstract:
The present invention provides novel radiopharmaceuticals comprising one to three pentapeptides, X X X X X , independently attached to a metal chelator or bonding moiety, C , to which is attached a Tc-99m, Re-186, or Re-188, optionally further comprising a linking group, L , between-the peptides and the chelator or bonding moiety. The pentapeptide sequence binds to the tuftsin receptor and is attached at the N-terminus to L or C. These radiopharmaceuticals are useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis.