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Milind Rajopadhye Phones & Addresses

  • 21 Honeysuckle Rd, Westford, MA 01886 (978) 392-9536
  • North Chelmsford, MA
  • North Billerica, MA

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Industries

Pharmaceuticals

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Resumes

Milind Rajopadhye Photo 1

Senior Director At Visen Medical Vp Chemistry At Visen Medical

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Location:
Greater Boston Area
Industry:
Pharmaceuticals
Experience:
VisEn Medical (Pharmaceuticals industry): Senior Director,  (-) VisEn Medical (Privately Held; Biotechnology industry): VP Chemistry,  (2002-Present) DuPont Pharmaceuticals Co (Pharmaceuticals industry): Associate Director,  (2000-20...

Publications

Us Patents

Radiopharmaceuticals For Imaging Infection And Inflammation

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US Patent:
6416733, Jul 9, 2002
Filed:
Oct 3, 1997
Appl. No.:
08/943659
Inventors:
John A. Barrett - Groton MA
Edward H. Cheesman - Lunenburg MA
Thomas D. Harris - Salem NH
Shuang Liu - Chelmsford MA
Milind Rajopadhye - Westford MA
Michael Sworin - Tyngsboro MA
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
A61K 5100
US Classification:
424 165, 424 169, 534 10
Abstract:
The present invention provides novel radiopharmaceuticals useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. The radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents provided by this invention are also useful for the treatment of diseases associated with infection and inflammation.

Fluorescent Imaging Agents

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US Patent:
2009022, Sep 3, 2009
Filed:
Jan 17, 2009
Appl. No.:
12/355777
Inventors:
Milind Rajopadhye - Westford MA,
Kevin Groves - Somerville MA,
Dorin V. Preda - Medford MA,
International Classification:
A61K 49/00
C07K 5/06
C07K 5/08
C07K 5/10
C07K 5/12
C07K 7/06
C07K 7/08
G01N 33/53
US Classification:
424 96, 530331, 530330, 530329, 530328, 530327, 530326, 530325, 530324, 530317, 436501
Abstract:
Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.

Pharmaceuticals For The Imaging Of Angiogenic Disorders

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US Patent:
2002000, Jan 3, 2002
Filed:
Mar 30, 1999
Appl. No.:
09/281474
Inventors:
MILIND RAJOPADHYE - WESTFORD MA,
D. SCOTT EDWARDS - BURLINGTON MA,
THOMAS D. HARRIS - SAMEL NH,
SHUANG LIU - CHELMSFORD MA,
PRAHLAD R. SINGH - ARLINGTON MA,
International Classification:
A61M036/14
A61K051/00
US Classification:
424/001690, 424/001650, 424/001110
Abstract:
The present invention describes novel compounds of the formula: useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.

Radiopharmaceuticals For Imaging Infection And Inflammation

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US Patent:
2003000, Jan 9, 2003
Filed:
Mar 27, 2002
Appl. No.:
10/109374
Inventors:
John Barrett - Groton MA,
Edward Cheesman - Lunenberg MA,
Thomas Harris - Salem NH,
Shuang Liu - Chelmsford MA,
Milind Rajopadhye - Westford MA,
Michael Sworin - Tyngsboro MA,
International Classification:
A61K051/00
A61M036/14
US Classification:
424/001650
Abstract:
The present invention provides novel radiopharmaceuticals useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. The radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents provided by this invention are also useful for the treatment of diseases associated with infection and inflammation.

Radiopharmaceuticals For Imaging Infection And Inflammation

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US Patent:
2003012, Jul 3, 2003
Filed:
May 20, 2002
Appl. No.:
10/151663
Inventors:
John Barrett - West Groton MA,
Edward Cheesman - Lunenburg MA,
Thomas Harris - Salem NH,
Shuang Liu - Chelmsford MA,
Milind Rajopadhye - Westford MA,
Michael Sworin - Tyngsboro MA,
International Classification:
A61K051/00
C 07D 4 3/02
US Classification:
424/001110, 540/474000
Abstract:
The present invention provides novel radiopharmaceuticals useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. The radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents provided by this invention are also useful for the treatment of diseases associated with infection and inflammation.

Imaging Thrombus With Glycoprotein Llb/Llla Antagonists

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US Patent:
2003015, Aug 14, 2003
Filed:
Nov 13, 2001
Appl. No.:
10/047691
Inventors:
Milind Rajopadhye - Westford MA,
John Barrett - Groton MA,
International Classification:
A61K051/00
US Classification:
424/001490
Abstract:
This invention relates to a method of using a radiolabeled small molecule antagonist of the platelet IIb/IIIa receptor for the diagnosis of arterial and venous thrombi.

Matrix Metalloproteinase Inhibitors

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US Patent:
2005028, Dec 29, 2005
Filed:
Aug 1, 2005
Appl. No.:
11/194845
Inventors:
Alan Carpenter - Carlisle MA,
Milind Rajopadhye - Westford MA,
Assignee:
Bristol-Myers Squibb Pharma Company - Princeton NJ
International Classification:
A61K049/00
C07F005/00
US Classification:
424009363, 534015000
Abstract:
Thus the present invention describes diagnostic agents comprising a diagnostic metal and a compound, wherein the compound comprises: 1-10 targeting moieties; a chelator; and 0-1 linking groups between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to the diagnostic metal. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in diagnosis of diseases associated with MMPs.

Biocompatible Fluorescent Silicon Nanoparticles

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US Patent:
2008010, May 1, 2008
Filed:
Jun 4, 2004
Appl. No.:
10/559558
Inventors:
Kirtland G. Poss - Marblehead MA,
Karen N. Madden - Sudbury MA,
Kevin Groves - Somerville MA,
Milind Rajopadhye - Westford MA,
International Classification:
A61K 49/00
G01N 33/53
A61P 43/00
US Classification:
424 96, 435 72
Abstract:
The invention features biocompatible fluorescent nanoparticle and their use in in vivo imaging methods.
Milind Rajopadhye from Westford, MA, age ~62 Get Report