Inventors:
Christopher Joseph Aquino - Long Beach WA
Milana Dezube - Chapel Hill NC
Ronald George Sherrill - Cary NC
Elizabeth Ellen Sugg - Durham NC
Jerzy Ryszard Szewczyk - Chapel Hill NC
Timothy Mark Willson - Durham NC
Assignee:
Glaxo Wellcome Inc. - Research Triangle Park NC
International Classification:
A01N 4362
C07D24324
C07D24312
Abstract:
A method of inducing a Cholescystokinin-A receptor agonist response in a mammal by administering a compound of formula (I), ##STR1## where R. sup. 1 is C. sub. 1 -C. sub. 6 alkyl, C. sub. 3-6 cycloalkyl, phenyl, or substituted phenyl; R. sup. 2 is C. sub. 3-6 alkyl, C. sub. 3-6 cycloalkyl, C. sub. 3-6 alkenyl, benzyl, phenylC. sub. 1-3 alkyl or substituted phenyl; or NR. sup. 1 R. sup. 2 together form 1,2,3,4-tetrahydroquinoline or benzazepine mono-, di-, or trisubstituted independently with C. sub. 1-6 alkyl, C. sub. 1-6 alkoxy or halogen substituents; n is an integer selected from the grouping consisting of 0,1,2 or 3; p is the integer 0 or 1; q is the integer 0 or 1; r is the integer 0 or 1, provided that when q is 0 then r is 0; R. sup. 3, R. sup. 4, R. sup. 5 and R. sup. 8 are selected from a variety of substituents; X is nitrogen, nitroso or R. sup. 8 ; m is an integer selected from the group consisting of 0, 1, 2 or 3; Y and Z are hydrogen or halogen, novel intermediates, a pharmaceutical composition for treating obesity, gall bladder stasis, disorders of pancreatic secretion, methods for such treatment and processes for preparing compounds of formula (I).
