Inventors:
- Smyrna GA, US
Arban Domi - Atlanta GA, US
Michael Hellerstein - Marietta GA, US
Farshad Guirakhoo - Atlanta GA, US
Nathanael Paul McCurley - Decatur GA, US
International Classification:
A61K 39/00
C12N 15/86
Abstract:
The compositions and methods are described for generating an immune response to an antigen. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens as a fusion product with a viral glycoprotein and matrix protein for generating a protective immune response to a subject to which the vector is administered. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat diseases.