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Michael P Groziak

from Hayward, CA
Age ~68

Michael Groziak Phones & Addresses

  • 3491 Skyline Dr, Hayward, CA 94542 (510) 537-1857
  • San Francisco, CA
  • 153 Primrose Way, Palo Alto, CA 94303 (650) 494-2141
  • 1500 Hickory Hill Dr, Effingham, IL 62401
  • Urbana, IL
  • Evanston, IL
  • Menlo Park, CA
  • Alameda, CA
  • Santa Clara, CA
  • 153 Primrose Way, Palo Alto, CA 94303

Education

Degree: Associate degree or higher

Emails

m***k@yahoo.com

Publications

Us Patents

Enzyme Catalyzed Therapeutic Agents

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US Patent:
6339151, Jan 15, 2002
Filed:
Jan 22, 1999
Appl. No.:
09/235961
Inventors:
H. Michael Shepard - Rancho Santa Fe CA
Michael P. Groziak - Palo Alto CA
Assignee:
NewBiotics, Inc. - San Diego CA
International Classification:
C07H 19073
US Classification:
536 268, 536 2854, 536 2855, 536 2711, 514 50, 514 51
Abstract:
This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous, intracellular enzyme in the cell which is enhanced in its expression as a result of selection by biologic or chemotherapy. This invention also provides methods and examples of molecules for selectively killing a pathological cell by contacting the cell with a prodrug that is a selective substrate for an endogenous, intracellular enzyme. The prodrug is subsequently converted to a cellular toxin. Further provided by this invention is a method for treating a pathology characterized by pathological, hyperproliferative cells in a subject by administering to the subject a prodrug that is a selective substrate for an endogenous, overexpressed, intracellular enzyme, and converted by the enzyme to a cellular toxin in the hyperproliferative cell.

Enzyme Catalyzed Therapeutic Activation

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US Patent:
6683061, Jan 27, 2004
Filed:
Oct 10, 2001
Appl. No.:
09/856127
Inventors:
H. Michael Shepard - Encinitas CA
Ming Fai Chan - Encinitas CA
Michael P. Groziak - Palo Alto CA
Assignee:
NewBiotics, Inc. - San Diego CA
International Classification:
A01N 4304
US Classification:
514 50, 514 42, 514 49, 514 43, 514 44, 514 45, 514 51, 536 172, 536 173
Abstract:
This invention provides novel substrate compounds that selectively inhibit the proliferation of pathological cells, for example, pathological calls that endogenously overexpress a target enzyme that confers resistance to biologic and chemotherapeutic agents. The enzyme acts on a substrate compound to 1) convert it to a cellular toxin and/or 2) release a toxic byproduct. In one embodiment, the activity of the target enzyme has been greatly enhanced in a target cell as a result of loss of tumor suppressor function and/or selection resulting from previous exposure to chemotherapy. In another embodiment, the pathological cell contains a target enzyme that is an expression product of an infectious agent in the cell. Further provided by this invention is a method for treating a subject by delivering to the subject a prodrug as described herein. The prodrugs of this invention may be used alone or in combination with other chemotherapeutics or alternative anti-cancer therapies such as radiation.

Enzyme Catalyzed Therapeutic Agents

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US Patent:
7601703, Oct 13, 2009
Filed:
Feb 12, 2001
Appl. No.:
09/782721
Inventors:
H. Michael Shepard - Rancho Sante Fe CA, US
Michael P. Groziak - Palo Alto CA, US
Assignee:
Celmed Oncology (USA), Inc. - Quebec
International Classification:
A61K 31/70
C07H 19/10
US Classification:
514 51, 536 268
Abstract:
This invention provides a method for identifying potential therapeutic agents by contacting a target cell with a candidate therapeutic agent which is a selective substrate for an endogenous, intracellular enzyme in the cell which is enhanced in its expression as a result of selection by biologic or chemotherapy. This invention also provides methods and examples of molecules for selectively killing a pathological cell by contacting the cell with a prodrug that is a selective substrate for an endogenous, intracellular enzyme. The prodrug is subsequently converted to a cellular toxin. Further provided by this invention is a method for treating a pathology characterized by pathological, hyperproliferative cells in a subject by administering to the subject a prodrug that is a selective substrate for an endogenous, overexpressed, intracellular enzyme, and converted by the enzyme to a cellular toxin in the hyperproliferative cell.

Enzyme Catalyzed Therapeutic Compounds

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US Patent:
7605144, Oct 20, 2009
Filed:
Oct 7, 2003
Appl. No.:
10/681418
Inventors:
H. Michael Shepard - Encinitas CA, US
Ming Fai Chan - Encinitas CA, US
Michael P. Groziak - Palo Alto CA, US
Assignee:
Celmed Oncology (USA), Inc. - Quebec
International Classification:
A61K 31/70
C07H 19/10
C12Q 1/66
C12P 29/00
C12P 31/00
US Classification:
514 51, 536 268, 435 8, 435 63, 435 64
Abstract:
This invention provides novel compounds selected from the group consisting of a 1,5-substituted pyrimidine derivative or analog and substituted furano-pyrimidone analogs. The compounds are useful to treat or prevent diseases such as cancer.

Boron Heterocycle Steroid Mimics And Associated Pharmaceutical Compositions And Methods Of Use

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US Patent:
60839368, Jul 4, 2000
Filed:
Jan 25, 1999
Appl. No.:
9/236948
Inventors:
Michael P. Groziak - Palo Alto CA
Assignee:
SRI International - Menlo Park CA
International Classification:
A01N 5558
C07C 6996
C07F 504
C07F 502
US Classification:
514 64
Abstract:
Boron heterocycle steroid mimics are provided that are useful as pharmaceutical agents, particularly in the treatment of estrogen-dependent disorders such as estrogen-dependent cancers. The compounds are also useful in diagnostic techniques such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), in boron neutron capture therapy, and in fluorescence emission-based modalities. Pharmaceutical formulations and methods of using the novel compounds are provided as well.

Boron Heterocycle Steroid Mimics And Associated Pharmaceutical Compositions And Methods Of Use

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US Patent:
62483056, Jun 19, 2001
Filed:
Jan 25, 2000
Appl. No.:
9/490601
Inventors:
Michael P. Groziak - Palo Alto CA
Assignee:
SRI International - Menlo Park CA
International Classification:
A61K 5100
A61K 3169
A61B 5055
C07F 504
C07F 502
US Classification:
424 161
Abstract:
Boron heterocycle steroid mimics are provided that are useful as pharmaceutical agents, particularly in the treatment of estrogen-dependent disorders such as estrogen-dependent cancers. The compounds are also useful in diagnostic techniques such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), in boron neutron capture therapy, and in fluorescence emission-based modalities. Pharmaceutical formulations and methods of using the novel compounds are provided as well.
Michael P Groziak from Hayward, CA, age ~68 Get Report