Inventors:
Michael Breslav - Maple Glen PA, US
Bruce Harris - Lansdowne PA, US
Birdella Kenney - North Wales PA, US
Thomas Maier - Stockach, DE
Armin Roessler - Tengen, DE
Frank Villani - Perkasie PA, US
Ulrich Weigl - Hilzingen, DE
Hua Zhong - Maple Glen PA, US
Assignee:
Ortho-McNeil Pharmaceutical Inc. - Raritan NJ
International Classification:
A61K 38/00
Abstract:
The present invention relates to novel processes for the preparation of peptidyl heterocyclic ketones of the general formula (I)wherein all variables are as herein defined. The present invention further relates to novel pharmaceutical salts and processes for their preparation. The peptidyl heterocyclic ketones of formula (I) are potent and selective inhibitors of tryptase, useful for the treatment and prevention of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis.