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Menachem Living Shoham

from Brooklyn, NY
Age ~80
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Also known as:
Menachem X Shoham, Menahem X Shoham
Connected to:
Amit Shoham, 41Shani Shoham, 47Shuki Shoham, 53Uri J Shoham, 82Michal Shohat, 52Ramez Shohdy, 53Mohammad Shohel, 47Mohammed Shohel, 40Grace C Shohet, 65Hilary E Shohoney, 38

Menachem Shoham Phones & Addresses

  • Brooklyn, NY
  • 4863 Donald Ave, Cleveland, OH 44143 (216) 382-2854 (216) 458-2784
  • Richmond Heights, OH
  • Akron, OH
  • 4863 Donald Ave, Cleveland, OH 44143 (216) 382-2854

Work

Position: Service Occupations

Education

Degree: Associate degree or higher

Emails

m***[email protected]

Resumes

Resumes

Menachem Shoham Photo 1

Associate Professor At Case Western Reserve University

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Position:
CSO at Designer Drug Development LLC, Associate Professor at Case Western Reserve University
Location:
Cleveland/Akron, Ohio Area
Industry:
Chemicals
Work:
Designer Drug Development LLC since 2008
CSO
Case Western Reserve University since 1990
Associate Professor
DuPont Aug 1987 - Jul 1988
Visiting Scientist
Education:
Yale University 1978 - 1981
postgraduate, Structural Biology Weizmann Institute of Science 1974 - 1978
PhD, Protein Crystallography Weizmann Institute of Science 1971 - 1973
MS, Protein Chemistry Bar-Ilan University 1962 - 1966
BS, Chemistry, Biochemistry
Skills:
Molecular Biology
Life Sciences
Drug Discovery
Biochemistry
Bioinformatics
Chemistry
In Vitro
Purification
Research
HPLC
Biotechnology
Science
Proteomics
Structural Biology
Protein Chemistry
Protein Purification
Protein Expression
Pharmacology
Microbiology
Computational Biology
Drug Design
Molecular Modeling
Pharmaceuticals
R&D
Teaching
Biophysics
Cell Biology
X-ray crystallography
Cell Culture
Fluorescence
Interests:
Drug discovery, virtual screening, structural biology, infectious diseases, quorum sensing, bacterial toxins, staphylococci
Menachem Shoham Photo 2

Associate Professor Of Biochemistry

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Location:
4863 Donald Ave, Cleveland, OH 44143
Industry:
Pharmaceuticals
Work:
Case Western Reserve University
Associate Professor
Education:
Weizmann Institute of Science 1974 - 1978
PhD, Life Sciences, crystallography
Skills:
Structural Biology
Drug Discovery
Biochemistry
Protein Chemistry
Molecular Biology
Protein Expression
Biophysics
Protein Purification
Science
R&D
Research
Biotechnology
Cell Biology
X Ray Crystallography
Cell Culture
Bioinformatics
Chemistry
Purification
Drug Design
Molecular Modeling
Genomics
Infectious Diseases
Life Sciences
Fluorescence
Western Blotting
Genetics
Pharmacology
Microbiology
Computational Biology
Teaching
Enzyme Kinetics
Mass Spectrometry
Dna
Cancer
Assay Development
In Vitro
Hplc
Cell
Pcr
Molecular Cloning
High Throughput Screening
Elisa
Proteomics
Pharmaceuticals
Laboratory
Microscopy
Spectroscopy
Immunology
Organic Chemistry
Analytical Chemistry
Interests:
Infectious Diseases
Staphylococci
Quorum Sensing
Structural Biology
Bacterial Toxins
Virtual Screening
Drug Discovery
Languages:
Hebrew
German
French
English
Menachem Shoham Photo 3

Associate Professor

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Location:
Cleveland, OH
Industry:
Biotechnology
Work:
Case Western Reserve University
Associate Professor

Business Records

Name / Title
Company / Classification
Phones & Addresses
Menachem Shoham
Invira Therapeutics, LLC
Mfg Pharmaceutical Preparations
11000 Cedar Ave, Cleveland, OH 44106

Publications

Us Patents

Anti-Virulence Compositions And Methods

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US Patent:
20110218226, Sep 8, 2011
Filed:
Mar 8, 2011
Appl. No.:
13/043049
Inventors:
MENACHEM SHOHAM - Cleveland OH, US
International Classification:
A61K 31/404
C12N 1/36
A61K 31/12
A61K 31/185
A61K 31/192
A61K 31/36
A61K 31/166
A61P 31/04
A61P 19/02
US Classification:
514411, 435245, 514685, 514576, 514568, 514687, 514569, 514465, 514615
Abstract:
A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.

Identification And Use Of Non-Peptide Analogs Of Rnaiii-Inhibiting Peptide For The Treatment Of Staphylococcal Infections

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US Patent:
20070293435, Dec 20, 2007
Filed:
Jun 15, 2007
Appl. No.:
11/763519
Inventors:
Naomi Balaban - Hopkinton MA, US
Menachem Shoham - Richmond Heights OH, US
International Classification:
A61K 38/06
G06F 19/00
US Classification:
514 18, 702 19
Abstract:
RNAIII inhibiting peptide (RIP) has been established as an effective inhibitor of staphylococcal infections. Non-peptide small molecule analogs based on a pharmacophore conforming to the putative atomic structure of RIP, can be identified by computer screening of that pharmacophore against established libraries of known small molecules other than peptides. One such identified structural analog is hamamelitannin. When tested for effective inhibition of staphylococcal infections, hamamelitannin demonstrated inhibition similar to that exhibited by RIP. Other analogs can be identified and similarly used.

Anti-Virulence Compositions And Methods

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US Patent:
20210308082, Oct 7, 2021
Filed:
Jan 29, 2019
Appl. No.:
16/260990
Inventors:
- Cleveland OH, US
Menachem Shoham - Cleveland OH, US
International Classification:
A61K 31/192
A61P 31/04
A61K 31/255
A61K 31/216
A61K 31/36
A61K 31/403
Abstract:
A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.

Use Of Hamamelitannin For The Treatment Of Staphylococcal Infections

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US Patent:
20150290227, Oct 15, 2015
Filed:
Jun 23, 2015
Appl. No.:
14/747977
Inventors:
Naomi Balaban - Hopkington MA, US
Menachem Shoham - Richmond Heights OH, US
International Classification:
A61K 31/7004
A61K 9/00
Abstract:
RNAIII inhibiting peptide (RIP) has been established as an effective inhibitor of staphylococcal infections. Non-peptide small molecule analogs based on a pharmacophore conforming to the putative atomic structure of RIP, can be identified by computer screening of that pharmacophore against established libraries of known small molecules other than peptides. One such identified structural analog is hamamelitannin. When tested for effective inhibition of staphylococcal infections, hamamelitannin demonstrated inhibition similar to that exhibited by RIP. Other analogs can be identified and similarly used.

Anti-Virulence Compositions And Methods

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US Patent:
20140336258, Nov 13, 2014
Filed:
Jul 29, 2014
Appl. No.:
14/445713
Inventors:
- Cleveland OH, US
Menachem Shoham - Cleveland OH, US
International Classification:
C07C 49/83
A61K 31/12
A61K 31/192
C07C 309/44
A61K 31/185
C07C 65/24
C07C 49/84
A61K 45/06
US Classification:
514568, 568331, 514685, 562 46, 514576, 562472, 568333, 514687
Abstract:
A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
Control profile
Menachem Living Shoham from Brooklyn, NY, age ~80 Get Report