Inventors:
Martin T. Zanni - Madison WI, US
John C. Wright - Oregon WI, US
Eric C. Fulmer - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12Q 1/68
G01N 33/53
A61K 38/00
C07K 1/00
C07H 21/02
US Classification:
435 6, 435 71, 530300, 530350, 536 231
Abstract:
This invention provides methods and devices for identifying and/or characterizing interactions involving molecules, including, but not limited to, identifying and/or characterizing interactions involving target molecules and candidate molecules. The present invention provides methods using multidimensional infrared spectrographic techniques, such as four wave mixing and pump-probe techniques, for identifying interactions involving biomolecules and therapeutic candidate molecules, and for characterizing such interactions in terms of their binding coefficients and/or equilibrium constants.
