Martin A Taubman

6827936, Dec 7, 2004

Apr 12, 1999

09/290049

Daniel J. Smith - Natick MA
Martin A. Taubman - Newtonville MA

Forsyth Dental Infirmary for Children - Boston MA

A61K 3902

4241901, 424 91, 424 92, 4241841, 4241851, 4241931, 42419711, 4242031, 4242341, 4242441, 435 691, 435183, 435193, 4352534, 530300, 530350, 536 231, 536 237

Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, an equivalent of aspartate 413, aspartate 451, an equivalent of aspartate 451, aspartate 562, and equivalent of aspartate 562, aspartate 567, an equivalent of aspartate 567, histidine 561, an equivalent of histidine 561, tryptophan 491, an equivalent of tryptophan 491, glutamate 489, an equivalent of glutamate 489, arginine 449, an equivalent of arginine 449, or combinations thereof. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.

7056517, Jun 6, 2006

Mar 9, 2004

10/797302

Daniel J. Smith - Natick MA, US
Martin A. Taubman - Newtonville MA, US

The Forsyth Institute - Boston MA

A61K 39/02
A61K 39/38
A61K 38/00
C07H 21/04

4241901, 424 91, 424 92, 4241841, 4241851, 4241931, 42419711, 4242341, 4242441, 435 691, 435183, 435193, 4352534, 530300, 530350

Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, an equivalent of aspartate 413, aspartate 451, an equivalent of aspartate 451, aspartate 562, an equivalent of aspartate 562, aspartate 567, an equivalent of aspartate 567, histidine 561, an equivalent of histidine 561, tryptophan 491, an equivalent of tryptophan 491, glutamate 489, an equivalent of glutamate 489, arginine 449, an equivalent of arginine 449, or combinations thereof. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.

7101562, Sep 5, 2006

May 1, 2000

09/562328

Andrew Lees - Silver Spring MD, US
Martin A. Taubman - Newton MA, US
Daniel J. Smith - Natick MA, US

The Forsyth Institute - Boston MA
Henry M. Jackson Foundation for the Advancement of Military Medicine - Rockville MD

A61K 39/09
A61K 39/02
A61K 39/385
A61K 39/116
C07H 1/00

4242441, 42419711, 4241941, 4242341, 4242031, 4241841, 424831, 514 23, 514 54, 514835, 530806, 53612312

The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer, preferably WSG, is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutans streptococcus.

7163682, Jan 16, 2007

Mar 9, 2004

10/797821

Daniel J. Smith - Natick MA, US
Martin A. Taubman - Newtonville MA, US

The Forsyth Institute - Boston MA

A61K 39/02
A61K 39/38
A61K 38/00

4241901, 424 91, 424 92, 4241841, 4241851, 4241931, 42419711, 4242031, 4242341, 4242441, 435 691, 435183, 435193, 4352534, 530300, 530350

Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in combination with peptide subunits of glucosyltransferase. Methods of provoking an immune response to glucan binding protein-B or glucosyltransferase. Methods of immunizing a mammal against dental caries are also described, along with antibodies which bind particular epitopes of glucan binding protein-B or glucosyltransferase.

7323175, Jan 29, 2008

Mar 7, 2003

10/383930

Daniel J. Smith - Natick MA, US
Martin A. Taubman - Newtonville MA, US

The Forsyth Institute - Boston MA

A61K 39/02
A61K 39/38
A61K 38/00

4241901, 424 91, 424 92, 4241841, 4241851, 4241931, 42419711, 4242031, 4242341, 4242441, 435 691, 435183, 435193, 4352534, 530300, 530350

Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in combination with peptide subunits of glucosyltransferase. Methods of provoking an immune response to glucan binding protein-B or glucosyltransferase. Methods of immunizing a mammal against dental caries are also described, along with antibodies which bind particular epitopes of glucan binding protein-B or glucosyltransferase.

20010048926, Dec 6, 2001

Nov 10, 1997

08/967573

DANIEL J. SMITH - NATICK MA, US
MARTIN A. TAUBMAN - NEWTONVILLE MA, US

A61K039/00
A61K039/38
A61K039/02
A61K039/385

424/190100, 424/184100

Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, aspartate 415 or both aspartate 413 and aspartate 415. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.

20070065465, Mar 22, 2007

Sep 5, 2006

11/516353

Andrew Lees - Silver Springs MD, US
Daniel Smith - Natick MA, US
Martin Taubman - Newtonville MA, US

A61K 39/09

424244100

The present invention provides glucan-based compositions and methods for stimulating an immune response against components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer, preferably WSG, is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan or to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a

56860757, Nov 11, 1997

Apr 30, 1993

8/057162

Martin A. Taubman - Newtonville MA
Daniel J. Smith - Natick MA

Forsyth Dental Infirmary for Children - Boston MA

A61K 3909

42419711

Immunization of animals with a composition containing either an amino acid sequence from the catalytic domain of glucosyltransferase, an amino acid sequence from the glucan-binding region of glucosyltransferase or an amino acid sequence from the native surface domain of glucosyltransferase provoke antibody and T-cell immune responses to this enzyme. Since this enzyme has been implicated in the colonization of mutans streptococci on tooth surfaces, such immune responses are important for the prevention of dental caries. Multicomponent and multivalent compositions which include these amino acid sequences provide effective vaccine capabilities.