Majid M Ali

45646007, Jan 14, 1986

Oct 26, 1982

6/436660

Majid Ali - Teaneck NJ
Madhava P. Ramanarayanan - Teaneck NJ

A61K 3900

436513

Allergenic factors are isolated from antigen extracts by preparing a column with pooled serum from patients with allergy to a given allergen system and passing over this column a pool of allergen extracts from different sources. Allergen specific immunoglobulin antibodies in purified form are obtained by forming an antigen-specific antibody complex from serum containing the antibodies and a material containing the antigen, recovering the complex and disassociating it, forming a second complex of the antigen with an excess of a second antibody so as to realize a combination of the second complex, free first specific antibody and free second specific antibody and then separating the second complex from the free first and second antibodies.

43091849, Jan 5, 1982

May 8, 1980

6/147845

Majid Ali - Teaneck NJ

G01N 3350
G01N 3396

23230B

Food or chemical allergy and intolerance is determined by comparing an analysis for a given analyzable constituent of a polymorphonuclear leukocyte with and without incubation with the incriminated food or chemical. Allergy or intolerance to the food or chemical under consideration causes the leukocytes to break down releasing the analyzable constituent and permitting its presence to be determined.

53191161, Jun 7, 1994

Feb 12, 1992

7/834644

Gary Viole - Ridgewood NJ
Majid Ali - Teaneck NJ

C07F 902

554 83

Disclosed are compositions comprising neutral, negatively and positively charged glycolipids phospholipids derived from lecithin, particularly lecithin fractions, and dilutions of lecithin or lecithin fractions. Also disclosed are methods for the preparation of such compositions, dosage units comprising these compositions, and methods of treatment of warm-blooded animals, preferably humans, with such compositions. These compositions are individually, collectively and selectively useful in the treatment of bacterial, viral, and skin infections and diseases.

42568331, Mar 17, 1981

Jan 8, 1979

6/001874

Majid Ali - Teaneck NJ
Alfred Fayemi - White Plains NY
Madhava P. Ramanarayanan - New York NY
Ricardo Mesa-Tejada - Briarcliff Manor NY

C12Q 166
C12N 1102
C12N 996

435 7

Horse radish peroxidase (HRP) is treated with phenyl isothiocyanate (PITC) to block the free amino groups on the enzyme. The PITC derivative of HRP is treated with periodate to oxidize the carbohydrate moiety on the enzyme, thus generating aldehyde groups. Gamma G globulin fraction (IgG) purified from an anti-human IgE serum is conjugated to the peroxidase-aldehyde by formation of a Schiff's base between the aldehyde group on the enzyme and the amino groups on the IgG. The Schiff's base is stabilized by reduction using the optimal amounts of sodium borohydride determined by tiration. A stable HRP-anti IgE IgG conjugate prepared thus is employed in a solid phase enzyme immunoassay for the detection of allergen specific IgE. The results of this assay can be used to determine a safe initial hypersensitization dosage level.

42012210, May 6, 1980

Apr 14, 1978

5/896296

Majid Ali - Teaneck NJ
Donald J. Nalebuff - Oakland NJ

A61B 500
A61B 600
A61B 900
A61B 1000

128630

An immunoglobulin-enzyme bridge technique for the detection of allergen-specific IgE antibodies in biologic fluids of atopic individuals is described.

44542267, Jun 12, 1984

Mar 17, 1982

6/358888

Majid Ali - Teaneck NJ
Donald Nalebuff - Oakland NJ
Alfred Fayemi - White Plains NY
Madhava P. Ramanarayanan - Teaneck NJ
Ricardo Mesa-Tejada - Briarcliff Manor NY

G01N 3354
C12N 996
C12N 1102
C12Q 128

435 7

An enzyme immunoassay for detecting an antigen in a biologic fluid or tissue which comprises contacting the fluid or tissue with an antibody specific for the antigen under binding conditions, at least one of the fluid or tissue and antibody having a solid component, contacting the resulting solid with a conjugate bindable with the antibody under binding conditions and determining the enzyme activity of the resulting solid phase is described. The conjugate is of peroxidase and an allergen, non-immunoglobulin protein or primary amino group containing drug having an average of 2-3 molecules of peroxidase per molecule of substance with an average molecular weight of about 30,000 daltons, prepared by reacting peroxidase previously treated with phenyl isothiocyanate and oxidized to form aldehyde groups with the substance to form a Schiff's base which is titrated with a reducing agent to form a stable conjugate.

62485911, Jun 19, 2001

Aug 31, 1999

9/386977

Majid Ali - Teaneck NJ

G01N 3348

436 63

A method of evaluating the safety of a herbal extract for parenteral use is described which consists of contacting blood cells with the extract and examining the blood cells for at least one membrane deformity. In addition, another method of evaluating the safety of a herbal extract for parenteral use is also described which consists of contacting plasma with the extract and examining the plasma for formation of a condition such as zones of congealing, microclots and microplaques.