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Mahesh V Padval

from Needham, MA
Age ~58

Mahesh Padval Phones & Addresses

  • 814 Central Ave, Needham, MA 02492 (781) 899-2951
  • 70 Pond St, Waltham, MA 02451
  • 70 Pond St #2, Waltham, MA 02451
  • 1400 Worcester Rd, Framingham, MA 01702 (508) 879-4190
  • 75 Saint Alphonsus St, Boston, MA 02120 (617) 738-9378
  • Roxbury Crossing, MA
  • Cambridge, MA

Publications

Us Patents

Solid Dispersion Formulations And Methods Of Use Thereof

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US Patent:
8591944, Nov 26, 2013
Filed:
Mar 7, 2012
Appl. No.:
13/414369
Inventors:
Mahesh V. Padval - Needham MA, US
Jeff T. Gautschi - Bend OR, US
Daniel T. Smithey - Bend OR, US
Marshall D. Crew - Bend OR, US
Abizer Harianawala - Acton MA, US
Assignee:
Zalicus Pharmaceuticals Ltd. - Vancouver
International Classification:
A61K 9/10
US Classification:
424465, 424464, 424484
Abstract:
The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e. g. , a spray dried dispersion or a hot melt extrusion.

Formulations, Conjugates, And Combinations Of Drugs For The Treatment Of Neoplasms

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US Patent:
20050080075, Apr 14, 2005
Filed:
Aug 25, 2004
Appl. No.:
10/925835
Inventors:
M. Nichols - Boston MA, US
Michael Foley - Chestnut Hill MA, US
Curtis Keith - Boston MA, US
Mahesh Padval - Waltham MA, US
Peter Elliott - Marlboro MA, US
International Classification:
C07D417/02
A61K031/5415
US Classification:
514225500, 514225800, 544042000, 544044000
Abstract:
The invention provides formulations and structural modifications for phenothiazine compounds which result in altered biodistributions, thereby reducing the occurrence of adverse reactions associated with this class of drug.

Therapeutic Regimens For Administering Drug Combinations

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US Patent:
20050112199, May 26, 2005
Filed:
Sep 23, 2004
Appl. No.:
10/947769
Inventors:
Mahesh Padval - Waltham MA, US
Peter Elliott - Marlboro MA, US
International Classification:
A61K009/22
US Classification:
424468000
Abstract:
The invention features dosing regimens for the administration of combination therapies, wherein one of the drugs of the combination is formulated for sustained release, or administered repeatedly, and compositions related thereto.

Methods And Reagents For The Treatment Of Diseases And Disorders Associated With Increased Levels Of Proinflammatory Cytokines

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US Patent:
20050153947, Jul 14, 2005
Filed:
Sep 20, 2004
Appl. No.:
10/947455
Inventors:
Mahesh Padval - Waltham MA, US
Palaniyandi Manivasakam - West Roxbury MA, US
Brendan Smith - Boston MA, US
Jason Fong - Philadelphia PA, US
Benjamin Auspitz - Cambridge MA, US
M. Nichols - Boston MA, US
Curtis Keith - Boston MA, US
Grant Zimmerman - Somervillle MA, US
Bradley Brasher - Natick MA, US
Noah Sachs - Boston MA, US
Todd Chappell - Boston MA, US
International Classification:
A61K031/573
A61K031/137
US Classification:
514171000, 514649000, 424472000
Abstract:
The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.

Compositions For The Treatment Of Neoplasms

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US Patent:
20060235001, Oct 19, 2006
Filed:
Apr 18, 2006
Appl. No.:
11/406213
Inventors:
Peter Elliott - Marlborough MA, US
Daniel Grau - Arlington MA, US
Mahesh Padval - Waltham MA, US
George Serbedzija - Sudbury MA, US
International Classification:
A61K 31/655
A61K 31/55
A61K 31/5415
A61K 31/538
A61K 31/473
A61K 31/496
US Classification:
514217000, 514225800, 514229800, 514250000, 514253030, 514297000, 514422000, 514150000, 514444000
Abstract:
The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient a composition that includes a phenothiazine and another active agent, where predetermined plasma drug levels are achieved and maintained for 12 hours or more.

Therapeutic Regimens For The Treatment Of Immunoinflammatory Disorders

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US Patent:
20090075955, Mar 19, 2009
Filed:
Sep 17, 2008
Appl. No.:
12/283989
Inventors:
Mahesh Padval - Waltham MA, US
Assignee:
CombinatoRx, Inc. - Cambridge MA
International Classification:
A61K 31/573
A61P 29/00
US Classification:
514170
Abstract:
The invention features pharmaceutical compositions and dosing regimens for the treatment of immunoinflammatory disorders.

Therapeutic Regimens For The Treatment Of Immunoinflammatory Disorders

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US Patent:
20110189293, Aug 4, 2011
Filed:
Dec 17, 2008
Appl. No.:
12/808477
Inventors:
Mahesh V. Padval - Waltham MA, US
Assignee:
CombinatoRx, Incoporated - Cambridge MA
International Classification:
A61K 9/14
A61K 31/519
A61K 31/56
US Classification:
424489, 5142621, 514171, 514170
Abstract:
A method for treating an immunoinflammatory disorder in a subject in need thereof, said method comprising administering to said subject a unit dosage form comprising dipyridamole coated onto acid beads and formulated for controlled release. The method further including administering a corticosteriod concurrently with administration of the dipyridamole.

Solid Dispersion Formulations And Methods Of Use Thereof

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US Patent:
20120252819, Oct 4, 2012
Filed:
Jun 12, 2012
Appl. No.:
13/494545
Inventors:
Mahesh V. Padval - Needham MA, US
Jeff T. Gautschi - Bend OR, US
Daniel T. Smithey - Bend OR, US
Marshall D. Crew - Bend OR, US
Abizer Harianawala - Acton MA, US
International Classification:
A61K 31/495
A61P 25/04
US Classification:
51425503
Abstract:
The present invention relates to formulations and methods for increasing the bioavailability of 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one, 1-(3,3-diphenylpropanoyl)piperazine, or a salt thereof. In particular, the formulation can include one or more pharmaceutically acceptable matrix polymers to form a solid dispersion, e.g., a spray dried dispersion or a hot melt extrusion.
Mahesh V Padval from Needham, MA, age ~58 Get Report