Inventors:
Georgia Theofan - Torrance CA
Lynn S. Grinna - Middleburg VA
Arnold Horwitz - Los Angeles CA
Assignee:
XOMA Corporation - Berkeley CA
International Classification:
C12N 1512
C12N 1500
A61K 39395
C07K 1900
Abstract:
Disclosed are novel hybrid fusion proteins comprising at their amino terminus, bactericidal/permeability-increasing protein or a biologically active fragment thereof and, at their carboxy terminus, at least one immunoglobulin heavy chain constant domain useful in treating bacterial infection. Also disclosed are DNA sequences encoding such proteins, recombinant methods for production of the proteins, and pharmaceutical preparations containing the recombinant products.