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Lynn Grinna Phones & Addresses

  • Boyce, VA
  • Millwood, VA
  • Upperville, VA
  • Middleburg, VA
  • Bluemont, VA
  • La Jolla, CA
  • Santa Monica, CA
  • San Diego, CA
  • PO Box 2260, Middleburg, VA 20118

Publications

Us Patents

Stable Bactericidal Permeability-Increasing Protein Products And Pharmaceutical Compositions Containing The Same

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US Patent:
6433140, Aug 13, 2002
Filed:
Oct 19, 1999
Appl. No.:
09/425034
Inventors:
Georgia Theofan - Torrance CA
Arnold Horwitz - Los Angeles CA
David Burke - Oakland CA
Manik Baltaian - Glendale CA
Lynn Grinna - Middleburg VA
Assignee:
XOMA Corporation - Berkeley CA
International Classification:
C07K 100
US Classification:
530350, 435 71, 435 6, 435 691
Abstract:
Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and state homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and in sequelae.

Stable Bactericidal/Permeability-Increasing Protein Products And Pharmaceutical Compositions Containing The Same

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US Patent:
6828418, Dec 7, 2004
Filed:
Jul 16, 2002
Appl. No.:
10/196460
Inventors:
Georgia Theofan - Torrance CA
Arnold Horwitz - Los Angeles CA
David Burke - Oakland CA
Manik Baltaian - Glendale CA
Lynn Grinna - Middleburg VA
Assignee:
Xoma Corporation - Berkeley CA
International Classification:
A61K 3800
US Classification:
530300, 530350, 514 12, 514 21, 435 71
Abstract:
Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

Stable Bactericidal/Permeability-Increasing Protein Products And Pharmaceutical Compositions Containing The Same

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US Patent:
20060009383, Jan 12, 2006
Filed:
Nov 3, 2004
Appl. No.:
10/980722
Inventors:
Georgia Theofan - Torrance CA, US
Arnold Horwitz - Los Angeles CA, US
David Burke - Oakland CA, US
Manik Baltaian - Glendale CA, US
Lynn Grinna - Middleburg VA, US
International Classification:
A61K 38/16
C07K 14/195
US Classification:
514012000, 530350000
Abstract:
Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

Stable Bactericidal/Permeability-Increasing Protein Products And Pharmaceutical Compositions Containing The Same

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US Patent:
58278168, Oct 27, 1998
Filed:
Jun 6, 1995
Appl. No.:
8/466822
Inventors:
Georgia Theofan - Torrance CA
Arnold Horwitz - Los Angeles CA
David Burke - Oakland CA
Manik Baltaian - Glendale CA
Lynn Grinna - Middleburg VA
Assignee:
Xoma Corporation - Berkeley CA
International Classification:
A61K 3817
US Classification:
514 2
Abstract:
Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.

Methods For The Preparation Of Endotoxin-Binding Proteins

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US Patent:
54398070, Aug 8, 1995
Filed:
May 19, 1993
Appl. No.:
8/072063
Inventors:
Lynn S. Grinna - Middleburg VA
Assignee:
Xoma Corporation - Berkeley CA
International Classification:
C07K 122
C12N 1512
US Classification:
435 691
Abstract:
Disclosed are improvements in methods for the isolation of endotoxin-binding proteins which are secreted by transfected host cells in appropriate cell culture media. In its preferred embodiment, the invention comprises addition of a cation exchange material to the media as the means of increasing the yield of recombinant endotoxin-binding proteins, such as bactericidal/permeability-increasing protein and lipopolysaccharide-binding protein.

Bpi-Immunoglobulin Fusion Proteins

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US Patent:
56435703, Jul 1, 1997
Filed:
May 19, 1993
Appl. No.:
8/064693
Inventors:
Georgia Theofan - Torrance CA
Lynn S. Grinna - Middleburg VA
Arnold Horwitz - Los Angeles CA
Assignee:
XOMA Corporation - Berkeley CA
International Classification:
C12N 1512
C12N 1500
A61K 39395
C07K 1900
US Classification:
4241341
Abstract:
Disclosed are novel hybrid fusion proteins comprising at their amino terminus, bactericidal/permeability-increasing protein or a biologically active fragment thereof and, at their carboxy terminus, at least one immunoglobulin heavy chain constant domain useful in treating bacterial infection. Also disclosed are DNA sequences encoding such proteins, recombinant methods for production of the proteins, and pharmaceutical preparations containing the recombinant products.

Bactericidal/Permeability-Increasing Protein (Bpi) Compositions

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US Patent:
62683454, Jul 31, 2001
Filed:
Feb 11, 2000
Appl. No.:
9/502286
Inventors:
Lynn S. Grinna - Upperville VA
Assignee:
Xoma Corporation - Berkeley CA
International Classification:
A61K 3816
US Classification:
514 12
Abstract:
Bactericidal/permeability increasing protein (BPI) and biologically active fragments, analogs and variants thereof are solubilized by lipid carriers including phospholipids, liposomes and nonionic detergents and stabilized against particle formation by poloxamer surfactants.

Bactericidal/Permeability-Increasing Protein (Bpi) Compositions

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US Patent:
60572930, May 2, 2000
Filed:
Apr 26, 1999
Appl. No.:
9/299321
Inventors:
Lynn S. Grinna - Upperville VA
Assignee:
Xoma Corporation - Berkeley CA
International Classification:
A61K 3816
US Classification:
514 12
Abstract:
Bactericidal/permeability increasing protein (BPI) and biologically active fragments, analogs and variants thereof are solubilized by lipid carriers including phospholipids, liposomes and nonionic detergents and stabilized against particle formation by poloxamer surfactants.
Lynn Sharon Grinna from Boyce, VA, age ~83 Get Report