US Patent:
20220296695, Sep 22, 2022
Inventors:
Chitrananda ABEYGUNAWARDANA - North Wales PA, US
Yadong Adam CUI - North Wales PA, US
Romulo FERRERO - North Wales PA, US
Jian HE - West Point PA, US
Luwy MUSEY - North Wales PA, US
Tanaz PETIGARA - North Wales PA, US
Julie M. SKINNER - West Point PA, US
- Rahway NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 39/09
A61K 47/20
A61P 31/04
A61P 37/04
Abstract:
The invention is related to multivalent immunogenic compositions comprising more than one polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an serotype conjugated to a carrier protein, wherein the serotypes of are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against infection and/or pneumococcal diseases caused by The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.