US Patent:
20110118313, May 19, 2011
Inventors:
Christian Lavedan - Potomac MD, US
Louis Licamele - Gaithersburg MD, US
Mihael H. Polymeropoulos - Potomac MD, US
International Classification:
A61K 31/4535
C12Q 1/68
C40B 30/00
A61K 31/138
A61P 25/00
A61P 25/18
US Classification:
514324, 435 6, 506 7, 514648, 514651
Abstract:
Molecular signature for antipsychotics and SERMs has been identified, namely their upregulation of genes that alter lipid homeostasis, preferably of one or more of the following genes: TNSIG1, SCD, FADS2, LDLR, FDPS, ACAT2, FDFT1, CYP51A1, FASN, DHCR7, RAB26, TM7SF2, SATB1, FAM117, GPNMB, NUPR1, VAC14, and LSS.