Linda M Liau

7192704, Mar 20, 2007

Mar 6, 2003

10/382945

Linda M. Liau - Los Angeles CA, US

The Regents of the University of California - Oakland CA

C12Q 1/68
G01N 33/53

435 6, 436501, 436518, 435 71, 435 723

The invention provides a method for inhibiting proliferation of neural cells. The neural cells can be tumor cells, glial cells, neuronal cells, and cells of the central or peripheral nervous systems. The method comprises contacting a neural cell with a molecule that disrupts the biological activity of a granulin molecule. In one embodiment, the molecule is an antibody directed against a granulin peptide. In other embodiments, the molecule is an antisense nucleotide directed against a granulin nucleic acid molecule, or a vaccine comprising a granulin peptide or a polynucleotide encoding a granulin peptide. The invention additionally provides methods for detecting and treating cancer in a neural tissue using granulin-related molecules. Also provided is a method for indenting differentially expressed gene products that are translated from mRNA species, using antibody-based screening of a cDNA expression library. This method, termed differential immuno-absorption (DIA), can be coupled to cDNA microarray hybridization and used in the identification of genes that play a role in the malignant progression of cancer.

7204982, Apr 17, 2007

Jul 2, 2002

10/188840

Linda M. Liau - Los Angeles CA, US

The Regents of the University of California - Oakland CA

A61K 39/395

4241301, 4241551, 4241851, 514 44, 536 231, 536 243

The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the brain, lung, breast, prostate and colon. The method comprises contacting a cancer cell with a molecule that disrupts the biological activity of a GDOX molecule. In one embodiment, the molecule is an antibody directed against a GDOX peptide. In other embodiments, the molecule is an antisense nucleotide directed against a GDOX nucleic acid molecule, or a vaccine comprising a GDOX peptide or a polynucleotide encoding a GDOX peptide. The invention additionally provides methods for detecting and treating cancer using GDOX-related molecules.

20020001586, Jan 3, 2002

Feb 28, 2001

09/795714

Linda Liau - Los Angeles CA, US

The Regents of the University of California

A61K048/00
A61K039/395

424/155100, 514/044000

The invention provides a method for inhibiting proliferation of neural cells. The neural cells can be tumor cells, glial cells, neuronal cells, and cells of the central or peripheral nervous systems. The method comprises contacting a neural cell with a molecule that disrupts the biological activity of a granulin molecule. In one embodiment, the molecule is an antibody directed against a granulin peptide. In other embodiments, the molecule is an antisense nucleotide directed against a granulin nucleic acid molecule, or a vaccine comprising a granulin peptide or a polynucleotide encoding a granulin peptide. The invention additionally provides methods for detecting and treating cancer in a neural tissue using granulin-related molecules. Also provided is a method for identifying differentially expressed gene products that are translated from mRNA species, using antibody-based screening of a cDNA expression library. This method, termed differential immuno-absorption (DIA), can be coupled to cDNA microarray hybridization and used in the identification of genes that play a role in the malignant progression of cancer.

20160367653, Dec 22, 2016

Sep 5, 2016

15/256683

- Oakland CA, US
Valerie A. Kickhoefer - Sherman Oaks CA, US
Sherven Sharma - Oakland CA, US
Steven M. Dubinett - Los Angeles CA, US
Isaac Yang - Los Angeles CA, US
Linda M. Liau - Los Angeles CA, US
Kathleen A. Kelly - Pacific Palisades CA, US
Jian Yang - Los Angeles CA, US
Upendra K. Kar - Oakland CA, US
Cheryl Champion - Greensboro GA, US
Janina Jiang - Los Angeles CA, US

A61K 39/00
A61K 38/19
A61K 38/45

The invention relates to compositions of vault complexes for use as adjuvants for stimulating a cellular immune response to an antigen, for example a tumor antigen, and methods of using the vault complexes in the treatment of diseases, such as cancer.

20150150821, Jun 4, 2015

Jul 9, 2013

14/411982

- Oakland CA, US
Valerie A. Kickhoefer - Sherman Oaks CA, US
Sherven Sharma - Oakland CA, US
Steven M. Dubinett - Los Angeles CA, US
Isaac Yang - Los Angeles CA, US
Linda M. Liau - Los Angeles CA, US
Kathleen A. Kelly - Pacific Palisades CA, US
Jian Yang - Los Angeles CA, US
Upendra K. Kar - Oakland CA, US
Cheryl Champion - Greensboro GA, US
Janina Jiang - Los Angeles CA, US

A61K 9/50
A61K 38/19
A61K 39/00
C07K 14/77
C07K 14/00

The invention relates to compositions of vault complexes for use as adjuvants for stimulating a cellular immune response to an antigen, for example a tumor antigen, and methods of using the vault complexes in the treatment of diseases, such as cancer.