Inventors:
Lily Y. Jan - San Francisco CA
Yuh Nung Jan - San Francisco CA
Yoshihiro Kubo - Tokyo, JP
Eithan Reuveny - San Francisco CA
Paul A. Slesinger - San Francisco CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12N 1512
C07K 14705
Abstract:
This disclosure relates to two separate and distinct inward rectifier K. sup. + channel expression products and the the genes which encode each expression product. The IRK1 gene (SEQ ID NO:1) encodes an inward rectifier K. sup. + channel and the GIRK1 gene (SEQ ID NO:3) encodes a G protein coupled muscarinic K. sup. + channel. The disclosure relates to the uses of these expression products, particularly in combination with identifying physiological processes mediated by these channels, such as regulation of heartbeat and insulin release and materials modulating or blocking same.