US Patent:
20120329861, Dec 27, 2012
Inventors:
Peter C. Brooks - Harpswell ME, US
Danielle Morais - Bedford Hills NY, US
Leonard Liebes - New York NY, US
Dorothy Rodriguez - Rowland Hts. CA, US
Assignee:
NEW YORK UNIVERSITY - New York NY
International Classification:
A61K 31/192
A61K 31/195
A61K 31/24
A61M 37/00
C12N 5/09
A61K 31/337
A61P 35/00
A61K 31/135
A61K 31/235
US Classification:
514449, 514646, 514568, 514567, 514535, 514543, 435375, 600 1
Abstract:
The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are methods of screening for benzoic derivatives based on their ability to inhibit the enzyme tyrosinase or to bind to and activate PXR/SXR xenobiotic receptors.