Lawrence M Kauvar

6444992, Sep 3, 2002

Sep 13, 1999

09/394842

Lawrence M. Kauvar - San Francisco CA
John Sedat - San Francisco CA

Trellis Bioscience, Inc. - Mountain View CA

G01N 2164

2504611, 2504581

An apparatus for high resolution, high throughput, three-dimensional fluorescence microscopy with a rotatable circular disc for mounting samples to be viewed and multiple CCDs and beam splitters as detectors for the fluorescence emission.

6492125, Dec 10, 2002

Jun 14, 1999

09/332613

Lawrence M. Kauvar - San Francisco CA
John Sedat - San Francisco CA

Trellis Bioscience, Inc. - Mountain View CA

G01N 3353

435 71, 435 792, 435 793, 435DIG 1, 435DIG 2, 435DIG 14, 435DIG 40, 435DIG 41, 436518

Particulate labels that can be individually identified comprise particulate supports to which are bound at least two distinguishable signal-generating moieties, such as fluorophores emitting at different wavelengths, which signals are detectable and measurable in situ. By varying the ratio and/or amounts of the signal-generating moieties, a multiplicity of different and distinguishable labels is obtained. Each different label can then be coupled to a different reagent and the individual interactions of each reagent with a target observed in parallel.

6642062, Nov 4, 2003

Sep 3, 1998

09/146984

Lawrence M. Kauvar - San Francisco CA
John Sedat - San Francisco CA

Trellis Bioinformatics, Inc. - San Francisco CA

G01N 33543

436518, 435 6, 435DIG 34, 435DIG 40, 435DIG 41, 536 231, 530333

Particulate labels that can be individually identified comprise particulate supports to which are bound at least two distinguishable signal generating moieties, such as fluorophores emitting at different wavelengths, which signals are detectable and measurable in situ. By varying the ratio and/or amounts of the signal generating moieties, a multiplicity of different and distinguishable labels is obtained. Each different label can then be coupled to a different reagent and the individual interactions of each reagent with a target observed in parallel.

6673554, Jan 6, 2004

Jun 14, 1999

09/332611

Lawrence M. Kauvar - San Francisco CA

Trellie Bioinformatics, Inc. - San Francisco CA

G01N 3353

435 71, 435 6, 435 72, 435 78, 436 35, 436 63

Intracellular translocation of proteins, particularly protein kinase C (PKC) isoenzymes, provides a surrogate test system for determining toxicity of candidate compounds. The profile of translocation with respect to at least one and preferably two or more signal transduction proteins can be correlated with that of known toxins. In addition, databases of such profiles with respect to toxins of various types provide a useful set of standards for evaluating toxicity of candidate compounds. Moreover, to the extent that a toxins profile mimics that found in a diseased state, the toxin can be used to construct screens for compounds alleviating the disease.

6806053, Oct 19, 2004

Jan 23, 2001

09/768661

J. Richard Sportsman - Palo Alto CA
Lawrence M. Kauvar - San Francisco CA

LJL BioSystems, Inc. - Sunnyvale CA

G01N 33533

435 71, 435 7021, 436518

Assays for detecting the presence and activity of cell-signaling components. These assays include luminescence polarization assays for detecting cell-signaling nucleotides and modulators of receptors and enzymes related to the generation and activity of such nucleotides.

RE38915, Dec 6, 2005

Dec 21, 2000

09/748665

Richard Sportsman - Palo Alto CA, US
Hugo O. Villar - Newark CA, US
Lawrence M. Kauvar - San Francisco CA, US
Wayne R. Spevak - Albany CA, US

Telik, Inc. - Palo Alto CA

A61K031/05
A61K031/10
A61K031/17
A61K031/655

514 4, 514150, 514477, 514483, 514562, 514563, 514596, 514597, 514598, 514617, 514618, 514619, 514616, 514708, 514762, 514866

Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein.

7029695, Apr 18, 2006

Jul 10, 2001

09/903442

Thomas Redelmeier - Vancouver, CA
Lawrence M. Kauvar - San Francisco CA, US
Robert T. Lum - Palo Alto CA, US
Matthew H. Lyttle - Point Reyes Station CA, US
Robert W. Macsata - Pleasanton CA, US
Steven R. Schow - Redwood Shores CA, US
Hugo O. Villar - La Jolla CA, US
Michael R. Kozlowski - Poway CA, US

Telik, Inc. - Palo Alto CA

A61K 9/127
A61K 38/06
C07K 5/08

424450, 514 18, 530331

Pharmaceutical compositions and methods of using them. Lipid formulations of a glutathione analog and methods of manufacturing them. Their use to stimulate hematopoiesis, protect hematopoietic cells from damage caused by radiation or chemotherapy, or potentiate the stimulatory action of one or a combination of cytokines on colony formation by hematopoietic progenitor cells, protect a subject from a destructive effect of a chemotherapeutic agent or irradiation, or to potentiate the effect of a chemotherapeutic agent.

7238490, Jul 3, 2007

Jul 21, 2005

11/187336

Lawrence M. Kauvar - San Francisco CA, US

Trellis Bioscience, Inc. - South San Francisco CA

G01N 33/53

435 71, 435 792, 436501, 436518

Intermolecular binding can be detected by formation of a “paratope” which results in an immediate generation of a signal. The substances to be tested for interaction are bound to demitopes, wherein said demitopes are components of a paratope which binds a reporter which provides said signal when bound. Known interactions measured in this way can also be employed to screen for compounds which interfere with the interactions. In addition to testing for individual interactions, the interaction of a compound with a library or library×library interactions can also be determined and the effect of potentially interfering substances evaluated.