Inventors:
James L. Miller - Los Altos CA
George P. Miljanich - Redwood City CA
Stephen S. Bowersox - Menlo Park CA
Laszlo Nadasdi - Walnut Creek CA
Assignee:
Elan Pharmaceuticals, Inc. - South San Francisco CA
International Classification:
C12Q 100
US Classification:
435 71, 435 4, 435 72, 435 721, 435967, 436 8, 436 63, 436149, 436501, 436806, 436815, 424 91, 424 92, 5142378, 5142388, 514255, 514315, 514567, 514626, 514428, 514613, 564194
Abstract:
Disclosed is a method of selecting analgesic agents based on their selective ability to block tetrodotoxin-insensitive sodium channels, particularly in comparison to blocking tetrodotoxin-sensitive sodium channels. Also disclosed is a novel class of compounds that is selective for blocking tetrodotoxin-insensitive sodium channels.