US Patent:
20070269481, Nov 22, 2007
Inventors:
Song Li - Orinda CA, US
Shyam Patel - Oakland CA, US
Craig Hashi - Berkeley CA, US
Ngan Huang - Mountain View CA, US
Kyle Kurpinski - Berkeley CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61F 2/06
A61K 31/727
A61K 31/728
B27N 3/28
D01D 5/10
US Classification:
424423000, 264465000, 264466000, 264516000, 424443000, 424078060, 424078080, 424093700, 42517480E, 425393000, 425403000, 514002000, 514054000, 623001410, 623001490, 623023760
Abstract:
The invention provides a composition comprising a nanofiber polymer in which the fibers of the nanofiber polymer are aligned, and a molecule is covalently attached, either directly or through a linker, to the nanofiber polymer. This molecule is capable of either covalently or non-covalently attaching to a member selected from an extracellular matrix component, a growth factor, and combinations thereof. The invention also provides methods of making the composition and methods of using the compositions to add new tissue to a subject, such as a human.