Inventors:
Geertruida M. Veldman - Sudbury MA, US
Monique V. Davies - Harpswell MA, US
Kening Song - Arlington MA, US
Neil M. Wolfman - Dover MA, US
Kristie Grove Bridges - Maynard MA, US
Anne Field - Royston, GB
Caroline Russell - Royston, GB
Viia Valge-Archer - Little Abington, GB
Assignee:
Wyeth LLC - Wilmington DE
International Classification:
A61K 39/00
A61K 39/395
C07K 16/00
C07K 16/18
C07K 16/22
US Classification:
4241301, 4241331, 4241351, 4241411, 4241421, 4241451, 4241581, 5303871, 5303873, 5303881, 53038815, 53038823, 53038824
Abstract:
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.