Inventors:
Thomas B. Causey - Gloucester MA, US
Lonnie O'Neal Ingram - Gainesville FL, US
Keelnatham Shanmugam - Gainesville FL, US
Shengde Zhou - Dekalb IL, US
Assignee:
University of Florida Research Foundation, Inc. - Gainesville FL
International Classification:
C12P 7/00
C12N 9/00
C12N 9/02
C12N 9/10
C12N 9/14
C12N 1/20
C12Q 1/68
C07H 21/04
C07H 21/02
C12N 9/04
US Classification:
435132, 435183, 435190, 435189, 435 61, 4352523, 435193, 435195, 43525233, 536 232, 536 231
Abstract:
The subject invention provides materials and methods wherein unique and advantageous combinations of gene mutations are used to direct carbon flow from sugars to a single product. The techniques of the subject invention can be used to obtain products from native pathways as well as from recombinant pathways. In preferred embodiments, the subject invention provides new materials and methods for the efficient production of acetate and pyruvic acid.