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Joseph H Degraw

from Norfolk, VA
Age ~47
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Also known as:
Joseph Hi Degraw, Joseph Henry Degraw, Joseph Rd Degraw, Joseph H Mcgraw, James W Neitzel
Related to:
Todd A Gaba, 49Tammy M Degraw, 60Christine J Degraw, 43Joanne M Taylor, 65Peter M Vanderlinden, 41Brian Kay, 43Kimberly M Monroe, 90Peter J Vanderlinden
Connected to:
Amber N Degraw, 34Ann M Degraw, 81Bryon K Degraw, 43Darren L Degraw, 58Jerry Degraw, 71Julia B Degraw, 42Randy Degraw, 46Rodney A Degraw, 69Daniel C Degray, 66David S Degray, 56

Joseph Degraw Phones & Addresses

  • Norfolk, VA
  • Andover, NJ
  • Denville, NJ
  • Portsmouth, VA
  • Virginia Beach, VA
  • Hamburg, NJ
  • Boonton, NJ
  • Suffolk, VA
  • 110 Aylwin Cres, Portsmouth, VA 23702

Publications

Us Patents

T-Butyl-Phenoxy-Alkylene Esters Of Benzoic And Nicotinic Acids, Compositions Containing Same And Their Antihistaminic Method Of Use

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US Patent:
44514743, May 29, 1984
Filed:
Dec 3, 1981
Appl. No.:
6/327141
Inventors:
Frank M. Berger - New York NY
Joseph I. DeGraw - Sunnyvale CA
Howard L. Johnson - Sunnyvale CA
International Classification:
C07D21355
C07C 6978
A61K 31455
US Classification:
424266
Abstract:
p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R. sub. 1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane; R. sub. 2 is lower alkyl having from one to three carbon atoms or hydrogen; R. sub. 3 is hydroxyl or an ester group selected from the group consisting of COOR. sub. 4 and OOCR. sub. 4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR. sub. 5 OOC and OOCR. sub. 5 COO derived from unsubstituted and hydroxy-substituted dicarboxylic acids, the acids being selected from the group consisting of aliphatic acids, including carbamic acid, having from one to about twelve carbon atoms; cycloaliphatic acids having from three to about twelve carbon atoms; carbocyclic aromatic acids having from six to about twenty carbon atoms; and nitrogen heterocyclic aromatic acids having from five to about twelve carbon atoms, R. sub. 4 being monovalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, and R. sub. 5 being divalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, the acids being esterified with aliphatic alcohols having from one to six carbon atoms; and carbonic acid monoalkyl esters, the alkyl having from one to three carbon atoms; and n. sub. 1, n. sub. 2 and n. sub.

P-Alkyl Or Cycloalkyl Phenoxy Alkanols And Alkanol Esters And Process For The Treatment Of Allergic Conditions

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US Patent:
45433623, Sep 24, 1985
Filed:
Jan 13, 1984
Appl. No.:
6/550838
Inventors:
Frank M. Berger - New York NY
Joseph I. DeGraw - Sunnyvale CA
Howard L. Johnson - Sunnyvale CA
International Classification:
A61K 3127
US Classification:
514480
Abstract:
p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R. sub. 1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane; R. sub. 2 is lower alkyl having from one to three carbon atoms or hydrogen; R. sub. 3 is hydroxyl or an ester group selected from the group consisting of COOR. sub. 4 and OOCR. sub. 4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR. sub. 5 OOC and OOCR. sub. 5 COO derived from unsubstituted and hydroxy-substituted dicarboxylic acids, the acids being selected from the group consisting of aliphatic acids, including carbamic acid, having from one to about twelve carbon atoms; cycloaliphatic acids having from three to about twelve carbon atoms; carbocyclic aromatic acids having from six to about twenty carbon atoms; and nitrogen heterocyclic aromatic acids having from five to about twelve carbon atoms, R. sub. 4 being monovalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, and R. sub. 5 being divalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, the acids being esterified with aliphatic alcohols having from one to six carbon atoms; and carbonic acid monoalkyl esters, the alkyl having from one to three carbon atoms; and n. sub. 1, n. sub. 2 and n. sub.

Purified Compositions Of 10-Propargyl-10-Deazaaminopterin And Methods Of Using Same In The Treatment Of Tumors

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US Patent:
60280719, Feb 22, 2000
Filed:
Mar 8, 1999
Appl. No.:
9/214984
Inventors:
Francis M. Sirotnak - New York NY
James R. Piper - Birmingham AL
Joseph I. DeGraw - Missoula MT
William T. Colwell - Menlo Park CA
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
SRI International - Menlo Park CA
Southern Research Institute - Birmingham AL
International Classification:
A61K 31505
C07D47508
US Classification:
514249
Abstract:
Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotrexate ("MTX") and are even superior to the newer clinical candidate edatrexate ("EDX"). Moreover, 10-propragyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growth several weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat human tumors, particularly human mammary tumors and human lung cancer.

Combinations Of 10-Propargyl-10-Deazaaminopterin And Taxols And Methods Of Using Same In The Treatment Of Tumors

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US Patent:
63232057, Nov 27, 2001
Filed:
Feb 17, 2000
Appl. No.:
9/505571
Inventors:
Francis M. Sirotnak - New York NY
James R. Piper - Birmingham AL
Joseph I. DeGraw - Missoula MT
William T. Colwell - Menlo Park CA
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
SRI International - Menlo Park CA
Southern Research Institute - Birmingham AL
International Classification:
A61K 31505
US Classification:
514249
Abstract:
Preliminary clinical studies in humans have now been done which show both the efficacy of 10-propargyl-10dAM and a preferred dosage schedule for such treatments. In addition, it has now been determined that combinations of 10-propargyl-10-deazaaminopterin (preferably highly purified forms, substantially free of 10-deazaaminopterin) with taxols exhibit synergistic effectiveness in the treatment of tumors. 10-propargyl-10-deazaaminopterin and a taxol in therapeutically effective amounts can be administered concurrently, one right after the other, or with a period of time in between.

P-Alkyl Phenoxy Alkanols For The Treatment Of Allergic Conditions

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US Patent:
50214608, Jun 4, 1991
Filed:
Dec 22, 1988
Appl. No.:
7/288778
Inventors:
Frank M. Berger - New York NY
Howard L. Johnson - Sunnyvale CA
Joseph I. DeGraw - Sunnyvale CA
International Classification:
A61K 31075
US Classification:
514718
Abstract:
p-Alkyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R. sub. 1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butul; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane; R. sub. 2 is lower alkyl having from one to three carbon atoms or hydrogen; R. sub. 3 is hydroxyl or an ester group selected from the group consisting of COOR. sub. 4 and OOCR. sub. 4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR. sub. 5 OOC and OOCR. sub. 5 COO derived from unsubstituted and hydroxy-substituted dicarboxylic acids, the acids being selected from the group consisting of aliphatic acids, including carbamic acid, having from one to about twelve carbon atoms; cycloaliphatic acids having from three to about twelve carbon atoms; carbocyclic aromatic acids having from six to about twenty carbon atoms; and nitrogen heterocyclic aromatic acids having from five to about twelve carbon atoms, R. sub. 4 being monovalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, and R. sub. 5 being divalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, the acids being esterified with aliphatic alcohols having from one to six carbon atoms; and carbonic acid monoalkyl esters, the alkyl having from one to three carbon atoms; and n. sub. 1, n. sub. 2 and n. sub.

Phenoxy Alkanol Esters For Treatment Of Allergic Conditions

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US Patent:
52429369, Sep 7, 1993
Filed:
May 21, 1990
Appl. No.:
7/526698
Inventors:
Frank M. Berger - New York NY
Joseph I. DeGraw - Sunnyvale CA
Howard L. Johnson - Sunnyvale CA
International Classification:
C07D21380
C07C 6978
A61K 3144
A61K 31235
US Classification:
514356
Abstract:
Compounds of the formula: ##STR1## wherein R. sub. 1 is at position 4 and either is an alkyl group of 1-6 C or is an --(CH. sub. 2). sub. 3 -- which is additionally linked to the phenyl at position 3 thereof; R. sub. 2 is a lower alkyl of 1-3 C or is hydrogen; n. sub. 1, n. sub. 2 and n. sub. 3 represent the number of CH. sub. 2, C(R. sub. 2). sub. 2 and CH. sub. 2 groups, respectively, wherein n. sub. 1 is 2, 3, 4, 5, 6, 8, or 11, n. sub. 2 is 0 or 1 and n. sub. 3 is 0 and R. sub. 4 is an alkyl residue of 1-12 C or is selected from phenyl and pyridyl; and their pharmaceutical compositions are useful in inhibiting the release of chemical mediators which cause allergic symptoms. Compounds, compositions, and methods for treatment of allergic conditions are disclosed.
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Joseph H Degraw from Norfolk, VA, age ~47 Get Report