Inventors:
Alfred M. Prince - Stamford CT
John Vnek - Bronx NY
Robert A. Neurath - New York NY
Christian Trepo - Bron, FR
Assignee:
The New York Blood Center, Inc. - New York NY
International Classification:
A61K 3912
Abstract:
A vaccine against viral heptitis comprising: A. antigenic particles having a particle size in the range of 30 to 50 nanometers, said antigenic particles containing heptitis B surface antigens; B. said antigen having less than 10 units of free antibody to heptitis B surface antigens per 1,000 units of hepatitis B surface antigens; C. at least 5% of the particles of said vaccine in the size range of 30 to 50 nanometers containing the hepatitis B surface antigenic specificity(s) which have been termed "e-antigen"; D. said heptatis B surface antigens, including e-antigens, being present in said vaccine in an amount sufficient to produce antibodies when introduced into a host animal, the balance being a medium which is physiologically acceptable, especially to humans and primates.