John R Sedivy

Gene targeting--the modification of genetic information within a living organism--is revolutionizing modern genetics. It offers new approaches to basic research and holds out the promise of eventual correction of defects in human cells. But what exactly is gene targeting? What is the history of this...

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimi...