John Schwier - Brownsburg IN, US Jerry Taylor - Indianapolis IN, US
International Classification:
A61K038/12 B29B009/00 A61K031/70
US Classification:
514/009000, 264/005000, 514/023000
Abstract:
A fluid bed spray process is described where one or more carbohydrates are incorporated into an echinocandin formulation to provide a significant improvement in thermal stability. The carbohydrate is solubilized with an echinocandin compound or echinocandin/carbohydrate complex in a solvent(s) to form a pharmaceutical solution which is sprayed onto the surface of a granular diluent or carrier. Alternatively, a granulating agent is added to the pharmaceutical solution which is then sprayed onto the surface of a non-granular diluent or carrier. The resulting granular oral formulations and medicaments derived therefrom are also described.