John J Egan

6509480, Jan 21, 2003

Oct 23, 2001

10/047182

Dilip R. Wagle - Nanuet NY
Sheng Ding Fang - Mahwah NJ
Ihor Terleckyj - Ridgewood NJ
John Resek - Brooklyn NY
John J. Egan - New York NY

Alteon, Inc. - Ramsey NJ

C07D40700

549299, 548525, 560126, 562510, 562511

Provided are, among other things, lipid-lowering or glucose-lowering methods and compounds, particularly lipid-lowering or glucose-lowering compounds, with an A-B ring structure as follows: wherein the dotted line between carbons 5 and 6, the dotted line between carbon 4 and R , and the dotted line between carbon 11 and R each independently represent an optional double bond from the respective numbered carbon to a linked carbon, and wherein X is hydroxy or, together with Y is oxy linking carbon 8 and carbon 12.

6790859, Sep 14, 2004

Jan 21, 2003

10/348378

Dilip R. Wagle - Nanuet NY
Taikyun Rho - Saddle Brook NJ
John J. Egan - NY NY
Sara Vasan - Yonkers NY
Peter Ulrich - Old Tappan NJ
Anthony Cerami - New York NY

Alteon Incorporated - Parsippany NJ

A61K 31425

514365

The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

7166625, Jan 23, 2007

Dec 31, 2001

10/037447

John J. Egan - New York NY, US
Dilip Wagle - New York NY, US
Sara Vasan - New York NY, US
Martin Gall - Morristown NJ, US
Stanley Bell - Narberth PA, US
Edmond J. LaVoie - Princeton Junction NJ, US

Alteon, Inc. - Parsippany NJ

A61K 31/42
C07D 263/00
C07D 263/30

514374, 514375, 514377, 548217, 548235, 548236

Provided, among other things, is a method of treating or ameliorating or preventing an indication of the invention in an animal, including a human comprising administering an effective amount of a compound of the formula I:.

7432254, Oct 7, 2008

Dec 31, 2001

10/038112

John J. Egan - New York NY, US
Dilip Wagle - New York NY, US
Sara Vasan - New York NY, US
Martin Gall - Morristown NJ, US
Stanley Bell - Narberth PA, US
Edmond Joseph LaVoie - Princeton Junction NJ, US

Synvista Therapeutics, Inc. - Montvale NJ

A61K 31/541
A61K 31/5377
A61K 31/426
A61K 31/53
A61K 31/501
A61K 31/497

5142102, 5142278, 5142355, 514365, 514242, 51425205, 51425505, 51425404, 514326, 514396, 514341

Provided is a method of treating or ameliorating or preventing glaucoma, decreasing intraocular pressure or improving or amemliorting ocular accommodation in an animal, including a human comprising administering an intraocular pressure decreasing or accommodation improving amount of a compound of the formula I:.

20020022622, Feb 21, 2002

Jan 19, 2001

09/766547

Dilip Wagle - New York NY, US
Sara Vasan - New York NY, US
John Egan - New York NY, US

A61K031/541
A61K031/5377
A61K031/496
A61K031/454
A61K031/421
A61K031/426

514/227800, 514/235500, 514/235800, 514/254020, 514/254040, 514/326000, 514/396000, 514/365000, 514/374000

Provided are, among other things, compounds of formula I or IA, . Also provided are methods of treatment with such compounds.

20020055527, May 9, 2002

Feb 23, 2001

09/792422

Dilip Wagle - New York NY, US
Sara Vasan - New York NY, US
John Egan - New York NY, US

A61K031/426
A61K031/428

514/365000, 514/367000

A method and compositions are disclosed for, among other things, in an animal, (i) improving the elasticity or reducing wrinkles of the skin, treating (ii) diabetes or treating or preventing (iii) adverse sequelae of diabetes, (iv) kidney damage, (v) damage to blood vasculature, (vi) hypertension, (vii) retinopathy, (viii) damage to lens proteins, (ix) cataracts, (x) peripheral neuropathy, or (xi) osteoarthritis.

20020160992, Oct 31, 2002

Oct 23, 2001

10/003514

Dilip Wagle - Nanuet NY, US
Taikyun Rho - Saddle Brook NJ, US
John Egan - New York NY, US
Sara Vasan - New York NY, US
Peter Ulrich - Old Tappan NJ, US
Anthony Cerami - New York NY, US

A61K031/541
A61K031/5377
A61K031/496
A61K031/55
A61K031/454
A61K031/427

514/210200, 514/217100, 514/227800, 514/236800, 514/254020, 514/326000, 514/365000

The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

20040198795, Oct 7, 2004

Apr 20, 2004

10/828051

Dilip Wagle - Nanuet NY, US
Veronica Mallon - New City NY, US
Sara Vasan - Yonkers NY, US
John Egan - Mountain Lakes NJ, US
Peter Ulrich - Old Tappan NJ, US
Anthony Cerami - New York NY, US

A61K031/4172
C07D233/61

514/400000, 548/335500

The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise substituted imidazolium compounds capable of inhibiting the formation of, as well as reversing already formed, advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.